2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(phenylmethoxy)methyl-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

Base Information

Chemical Name:2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(phenylmethoxy)methyl-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-
CAS No.:171357-44-1
Molecular Formula:C28H25NO7
Molecular Weight:487.5
Hs Code.:
Mol file:171357-44-1.mol

Synonyms:2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(phenylmethoxy)methyl-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(phenylmethoxy)methyl-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

Chemical Property:

Melting Point:80 - 81 °C
PSA：100.16000
LogP:4.09000

Purity/Quality:

Safty Information:

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Technology Process of 2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(phenylmethoxy)methyl-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

There total 2 articles about 2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(phenylmethoxy)methyl-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 171357-43-0
(1S,5S)-7-endo-8-exo-dibenzoyloxy-6-exo-hydroxymethyl-2-oxa-4-azabicyclo[3.3.0]octan-3-one

: 171357-44-1
(1S,5S)-7-endo-8-exo-dibenzoyloxy-6-exo-benzyloxymethyl-2-oxa-4-azabicyclo[3.3.0]octan-3-one

Guidance literature:: With trifluorormethanesulfonic acid; In 1,2-dichloro-ethane; for 4h; Ambient temperature;
DOI:10.1016/S0008-6215(96)00172-3

Reference yield:

: 165375-27-9
(1R,2R,3S,4S,5R)-4-(ethoxycarbonylamino)-3-hydroxy-5-(hydroxymethyl)cyclopentane-1,2-diyl dibenzoate

: 171357-44-1
(1S,5S)-7-endo-8-exo-dibenzoyloxy-6-exo-benzyloxymethyl-2-oxa-4-azabicyclo[3.3.0]octan-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / (Bu₃Sn)2O / toluene / 10 h / Heating

2: 74 percent / TfOH / 1,2-dichloro-ethane / 4 h / Ambient temperature

With trifluorormethanesulfonic acid; bis(tri-n-butyltin)oxide; In 1,2-dichloro-ethane; toluene;
DOI:10.1016/S0008-6215(96)00172-3

Reference yield:

: 171357-44-1
(1S,5S)-7-endo-8-exo-dibenzoyloxy-6-exo-benzyloxymethyl-2-oxa-4-azabicyclo[3.3.0]octan-3-one

: 172337-03-0
(3aS,4R,5R,6S,6aS)-4-Benzyloxymethyl-2-dimethylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-5,6-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Me₃OBF₄, 4A molecular sieves / 1.) CH₂Cl₂, rt, 24 h, 2.) CH₂Cl₂, 24 h

2: 85 percent / methanol; triethylamine; H₂O / 72 h / Ambient temperature

With 4 A molecular sieve; trimethoxonium tetrafluoroborate; In methanol; water; triethylamine;
DOI:10.1016/S0008-6215(96)00172-3