cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole

Base Information

• Chemical Name: cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole
• CAS No.: 876130-70-0
• Molecular Formula: C₇H₁₄N₂
• Molecular Weight: 126.202
• Mol file: 876130-70-0.mol

Synonyms:cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole

Chemical Property of cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole

Chemical Property:

• PSA: 15.27000
• LogP: 0.17660

Purity/Quality:

98.5% ^*data from raw suppliers

cis-5-Methyloctahydropyrrolo[3,4-b]pyrrole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole

There total 10 articles about cis-5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3aR,6aR)-5-methyl-1-[(1R)-1-phenylethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[3,2-c]pyrrole (1421372-15-7) → (3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-b]pyrrole (948846-61-5,132414-59-6,876130-70-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 70 ℃; for 24h; under 2327.23 Torr;

Reference yield: 97.19%

cis-tert-butyl hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate (180975-51-3) → cis-5-methyloctahydropyrrolo[2,3-c]pyrrole (132414-59-6,876130-70-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃; for 2h; Inert atmosphere;

Reference yield:

(3aR,6aR)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester (948846-60-4) → (3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-b]pyrrole (948846-61-5,132414-59-6,876130-70-0)

Guidance literature:

(3aR,6aR)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester; With hydrogenchloride; water; In methanol; at 20 ℃;

With sodium hydroxide; In water; pH=9 - 10;

upstream raw materials:

2-benzyl-7-methyl-2,7-diazabicyclo[3.3.0]octane

(3aR,6aR)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester

(3aR,6aR)-5-methyl-1-[(1R)-1-phenylethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[3,2-c]pyrrole

(3aR,6aR)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,2-c]pyrrole

Refernces

• 1、 -. "Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection". Page/Page column 121; 122. . Retrieved 2018/10/25.
• 2、 -. "OCTAHYDRO-PYRROLO[3,4-B]PYRROLE N-OXIDES". Page/Page column 20. . Retrieved 2009/04/25.