180975-51-3

Basic information

• Product Name: (cis)-5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole
• Synonyms: (cis)-5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole;5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole ;Cis-5-Boc-1H-Hexahydropyrrolo[3,4-b]pyrrole;cis-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate;(3aS,6aS)-1-tert-butyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate;cis-Hexahydropyrrolo[3,4-b]pyrrole-5-carboxylic acid tert-butyl ester;tert-Butyl cis-hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate;(3aS, 6aS)-Hexahydro-pyrrolo[3,4-b]pyrrole-5-carboxylic acid tert-butyl ester
• CAS NO: 180975-51-3
• Molecular Formula: C11H20N2O2
• Molecular Weight: 212.2887
• Mol File: 180975-51-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 295.397 °C at 760 mmHg
• Flash Point: 132.451 °C
• Appearance: /
• Density: 1.076
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.494
• PKA: 10.72±0.20(Predicted)
• CAS DataBase Reference: (cis)-5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: (cis)-5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole(180975-51-3)
• EPA Substance Registry System: (cis)-5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole(180975-51-3)

Safety Data

• Hazardous Substances Data: 180975-51-3(Hazardous Substances Data)

Usage

Uses

cis-Hexahydropyrrolo[3,4-b]pyrrole-5-carboxylic Acid tert-Butyl Ester is used in preparation of Pyridoindole for the treatment and prophylaxis of bacterial infection.

InChI:InChI=1/C11H20N2O2/c1-11(2,3)15-10(14)13-6-8-4-5-12-9(8)7-13/h8-9,12H,4-7H2,1-3H3/t8-,9+/m0/s1

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 128740-02-3 ethyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate 
• 128740-03-4 N-allyl-N-(2-oxoethyl)carbamic acid,ethyl ester 
• 132414-78-9 ethyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate 
• 132414-50-7 1-benzyl-octahydropyrrolo[2,3-c]pyrrole 
• 132414-80-3 tert-butyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate 
• 370880-03-8 (3aR,6aR)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,2-c]pyrrole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1438080-49-9 tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3.4-b]pyrrole-5(1H)carboxylate 
• 132414-59-6 cis-5-methyloctahydropyrrolo[2,3-c]pyrrole 
• 132414-59-6 cis-5-methyloctahydropyrrolo[2,3-c]pyrrole 
• 948846-79-5 (3aR,6aR)-5-methyl-1-(4-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)-phenyl)-octahydro-pyrrolo[3,4-b]pyrrole 

Relevant articles and documents

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The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.

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Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.