α,α,4-Trimethylbenzeneacetic acid ethyl ester

Base Information

• Chemical Name: α,α,4-Trimethylbenzeneacetic acid ethyl ester
• CAS No.: 32454-24-3
• Molecular Formula: C13H18O2
• Molecular Weight: 206.285
• Hs Code.: 2916399090
• Mol file: 32454-24-3.mol

Synonyms:α,α,4-Trimethylbenzeneacetic acid ethyl ester;ethyl 2-methyl-2-(p-tolyl)propanoate

Chemical Property of α,α,4-Trimethylbenzeneacetic acid ethyl ester

Chemical Property:

• Boiling Point: 271.3±9.0 °C(Predicted)
• PSA: 26.30000
• Density: 0.987±0.06 g/cm3(Predicted)
• LogP: 2.83570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α,α,4-Trimethylbenzeneacetic acid ethyl ester

There total 5 articles about α,α,4-Trimethylbenzeneacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-tolylacetic acid ethyl ester (14062-19-2) → 2-methyl-2-p-tolyl-propionic acid ethyl ester (32454-24-3)

Guidance literature:

With NaH; methyl iodide; In water; N,N-dimethyl-formamide;

Reference yield:

(4-methylphenyl)acetonitrile (2947-61-7) → 2-methyl-2-p-tolyl-propionic acid ethyl ester (32454-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: (methylation)

2: aq. KOH / ethane-1,2-diol / Heating

With potassium hydroxide; In ethylene glycol;

DOI:10.1021/ja01010a030

Reference yield:

2-methyl-2-(4-methylphenyl)propionitrile (40119-34-4) → 2-methyl-2-p-tolyl-propionic acid ethyl ester (32454-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / ethane-1,2-diol / Heating

With potassium hydroxide; In ethylene glycol;

DOI:10.1021/ja01010a030

upstream raw materials:

ethanol

2-methyl-2-(p-tolyl)propanoic acid

(4-methylphenyl)acetonitrile

2-methyl-2-(4-methylphenyl)propionitrile

Downstream raw materials:

2,2-Dimethyl-2-(4-methylphenyl)ethanol

2-(4-Bromomethyl-phenyl)-2-methyl-propionic acid ethyl ester

2-methyl-2-(4-methylphenyl)propionaldehyde

2,3-dimethyl-2,3-di-p-tolyl-butane

Refernces

• 1、 -. "Synthesis of terfenadine and derivatives". . . Retrieved 2008/06/13.