2-BroMo-6-fluoro-3-Methylbenzyl alcohol

Base Information

• Chemical Name: 2-BroMo-6-fluoro-3-Methylbenzyl alcohol
• CAS No.: 1375069-06-9
• Molecular Formula: C8H8BrFO
• Molecular Weight: 219.053
• Mol file: 1375069-06-9.mol

Synonyms:2-BroMo-6-fluoro-3-Methylbenzyl alcohol

Chemical Property of 2-BroMo-6-fluoro-3-Methylbenzyl alcohol

Chemical Property:

• PSA: 20.23000
• LogP: 2.38890
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-6-fluoro-3-methylbenzylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-6-fluoro-3-Methylbenzyl alcohol

There total 2 articles about 2-BroMo-6-fluoro-3-Methylbenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-6-fluoro-3-methylbenzaldehyde (154650-16-5) → (2-bromo-6-fluoro-3-methylphenyl)methanol (1375069-06-9)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

2-bromo-4-fluorotoluene (1422-53-3) → (2-bromo-6-fluoro-3-methylphenyl)methanol (1375069-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran;

Reference yield: 90.0%

(2-bromo-6-fluoro-3-methylphenyl)methanol (1375069-06-9) → 3-bromo-2-(bromomethyl)-1-fluoro-4-methylbenzene

Guidance literature:

With phosphorus tribromide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-bromo-6-fluoro-3-methylbenzaldehyde

2-bromo-4-fluorotoluene

Downstream raw materials:

C₉H₇BrFN

C₉H₁₁BrFN

C₁₄H₁₉BrFNO₂

C₁₄H₁₆FN₃O