154650-16-5

Basic information

• Product Name: 2-BROMO-6-FLUORO-3-METHYLBENZALDEHYDE
• Synonyms: 2-BROMO-6-FLUORO-3-METHYLBENZALDEHYDE;Benzaldehyde, 2-broMo-6-fluoro-3-Methyl-
• CAS NO: 154650-16-5
• Molecular Formula: C8H6BrFO
• Molecular Weight: 217.04
• EINECS: 1312995-182-4
• Mol File: 154650-16-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 248.1℃
• Flash Point: 103.9℃
• Appearance: /
• Density: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-BROMO-6-FLUORO-3-METHYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6-FLUORO-3-METHYLBENZALDEHYDE(154650-16-5)
• EPA Substance Registry System: 2-BROMO-6-FLUORO-3-METHYLBENZALDEHYDE(154650-16-5)

Safety Data

• Hazardous Substances Data: 154650-16-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-6-fluoro-3-methylbenzaldehyde is a chemical compound with the molecular formula C8H6BrFO. It is a derivative of benzaldehyde, with bromine and fluorine substitutions on the 2 and 6 positions, and a methyl group attached to the 3 position. 2-BROMO-6-FLUORO-3-METHYLBENZALDEHYDE is often used in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. Its distinctive structure and reactivity make it a valuable building block for creating more complex organic compounds through various chemical reactions. It is important to handle this compound with care, as it is a toxic substance and can cause skin and eye irritation.

Upstream product

• 1422-53-3 2-bromo-4-fluorotoluene 
• 109-94-4 formic acid ethyl ester 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1056214-74-4 2-bromo-6-methoxy-3-methylbenzaldehyde 
• 1404115-09-8 C₂₂H₂₀F₄N₄O₃ 
• 1404115-08-7 C₂₃H₂₂F₄N₄O₃ 
• 1404115-67-8 C₁₄H₁₆FN₃O 
• 1256483-11-0 C₉H₇BrFN 

Relevant articles and documents

Dihydroisocoumarin derivative and preparation method and application thereof

The present invention discloses a dihydroisocoumarin derivative and preparation method and application thereof, the dihydroisocoumarin derivative having a structure as shown in formula (I) or (II). The method of preparing dihydroisocoumarin derivatives of

Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors

A series of exiguamine A analogues were designed and synthesized via 15 steps. Their inhibitory activities against IDO1 were tested and the structure-activity relationships were studied. Most compounds exhibited potent IDO1 inhibitory activities with IC50 values at the level of 10?7–10?8 M. Compound 21f was the most potent IDO1 inhibitor with an IC50 value of 65.3 nM, which was comparable with the positive control drug epacadostat (IC50 = 46 nM). Moreover, compound 21f showed higher selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) and no cytotoxicity at its effective concentration, rending it justifiable for further optimization and evaluation.

QUINOXALINE DERIVATIVES

The present invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.