tert-Butyl 3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate
CAS No.:1395498-37-9
Molecular Formula:C14H21NO5
Molecular Weight:283.32024
Hs Code.:2933399090
Mol file:1395498-37-9.mol

Synonyms:tert-Butyl 3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate;3-(2-Ethoxy-2-oxoethylidene)-4-oxo-1-piperidinecarboxylic Acid 1,1-DiMethylethyl Ester

Suppliers and Price of tert-Butyl 3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(2-Ethoxy-2-oxoethylidene)-4-oxo-1-piperidinecarboxylicAcid1,1-DimethylethylEster
1.5g
$ 1100.00

Medical Isotopes, Inc.
3-(2-Ethoxy-2-oxoethylidene)-4-oxo-1-piperidinecarboxylicAcid1,1-DimethylethylEster
150 mg
$ 625.00

Crysdot
tert-Butyl3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate 95+%
1g
$ 432.00

Chemenu
tert-butyl(Z)-3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate 95%
1g
$ 408.00

Chemcia Scientific
(E)-Tert-butyl3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate ＞95%
0.5 G
$ 195.00

Alichem
tert-Butyl3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate
1g
$ 400.00

Total 4 raw suppliers

Chemical Property of tert-Butyl 3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate

Chemical Property:

PSA：72.91000
LogP:1.62370

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Ethoxy-2-oxoethylidene)-4-oxo-1-piperidinecarboxylicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-(2-Ethoxy-2-oxoethylidene)-4-oxo-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is used in the synthesis of Clopidogrel (C587250), an antithrombotic agent.

Technology Process of tert-Butyl 3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate

There total 5 articles about tert-Butyl 3-(2-ethoxy-2-oxoethylidene)-4-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.76%

: 924-44-7
glyoxylic acid ethyl ester

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1395498-37-9
(Z)-(1-tert-butoxycarbonyl-4-oxo-piperidin-3-ylidene)ethyl acetate

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; With morpholine; toluene-4-sulfonic acid; In toluene; for 3h; Reflux;

glyoxylic acid ethyl ester; With toluene-4-sulfonic acid; In toluene; for 2h; Reflux;

Reference yield: 32.9%

: C₁₄H₂₃NO₅

: 1395498-37-9
C₁₄H₂₁NO₅

Guidance literature:: C₁₄H₂₃NO₅; With bromine; In tetrahydrofuran; at -45 ℃; for 3h;

With triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield: 29.7%

: 924-44-7
glyoxylic acid ethyl ester

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1395498-37-9
(E)-(1-tert-butoxycarbonyl-4-oxo-piperidin-3-ylidene)ethyl acetate

: 1395498-37-9
(Z)-(1-tert-butoxycarbonyl-4-oxo-piperidin-3-ylidene)ethyl acetate

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; With pyrrolidine; toluene-4-sulfonic acid; In toluene; for 3h; Reflux;

glyoxylic acid ethyl ester; With toluene-4-sulfonic acid; In toluene; Reflux;