6N-HydroxyMethyl Tenofovir Disoproxil

Base Information

Chemical Name:6N-HydroxyMethyl Tenofovir Disoproxil
CAS No.:1244022-53-4
Molecular Formula:C20H32N5O11P
Molecular Weight:549.468741
Hs Code.:
Mol file:1244022-53-4.mol

Synonyms:6N-HydroxyMethyl Tenofovir Disoproxil;6N-HydroxyMethyl Tenofovir Disoproxil Discontinued See: M264450;(R)-(((((1-(6-((hydroxymethyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(oxy))bis(methylene) diisopropyl bis(carbonate)

Suppliers and Price of 6N-HydroxyMethyl Tenofovir Disoproxil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of 6N-HydroxyMethyl Tenofovir Disoproxil

Chemical Property:

Boiling Point:687.9±65.0 °C(Predicted)
PKA:13.41±0.10(Predicted)
PSA：201.49000
Density:1.45±0.1 g/cm3(Predicted)
LogP:2.88810
Storage Temp.:Refrigerator
Solubility.:Dichloromethane, Ethyl Acetate

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Intermediate in the preparation of Tenofovir Disoproxil Fumarate (T018505).

Technology Process of 6N-HydroxyMethyl Tenofovir Disoproxil

There total 5 articles about 6N-HydroxyMethyl Tenofovir Disoproxil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 201341-05-1
tenofovir disoproxil

: 1244022-53-4
C₂₀H₃₂N₅O₁₁P

Guidance literature:: With formic acid; In acetonitrile; at 50 - 70 ℃; Inert atmosphere;

Reference yield:

: 35180-01-9
chloromethyl isopropyl carbonate

: 147127-20-6
tenofovir

: 1244022-55-6
C₁₅H₂₄N₅O₈P

: 1244022-53-4
C₂₀H₃₂N₅O₁₁P

: 201341-05-1
tenofovir disoproxil

: 211364-69-1
Tenofovir mono-POC

Guidance literature:: tenofovir; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 45 ℃;

chloromethyl isopropyl carbonate; With tetrabutylammomium bromide; In 1-methyl-pyrrolidin-2-one; at 45 - 50 ℃; for 5.5h;
DOI:10.1021/op1001337

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 1244022-55-6
C₁₅H₂₄N₅O₈P

: 1244022-53-4
C₂₀H₃₂N₅O₁₁P

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide / 120 °C

2.1: magnesium 2-methylpropan-2-olate / 1-methyl-pyrrolidin-2-one / 70 - 74 °C

3.1: chloro-trimethyl-silane; sodium bromide / 1-methyl-pyrrolidin-2-one / 0 - 75 °C

4.1: triethylamine / 1-methyl-pyrrolidin-2-one / 45 °C

4.2: 5.5 h / 45 - 50 °C

With chloro-trimethyl-silane; magnesium 2-methylpropan-2-olate; triethylamine; sodium bromide; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1021/op1001337