4-Methoxyindan-1-ol

Base Information

• Chemical Name: 4-Methoxyindan-1-ol
• CAS No.: 67199-57-9
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• European Community (EC) Number: 821-481-0
• DSSTox Substance ID: DTXSID101286397
• Nikkaji Number: J1.764.848I

Synonyms:67199-57-9;4-methoxyindan-1-ol;4-methoxy-2,3-dihydro-1H-inden-1-ol;2,3-DIHYDRO-4-METHOXY-1H-INDEN-1-OL;4-methoxy-1-indanol;SCHEMBL1508668;ZKRBOZAOAJXXGP-UHFFFAOYSA-N;DTXSID101286397;AKOS010641991;1H-Inden-1-ol, 2,3-dihydro-4-methoxy-;EN300-152295;N12758

Chemical Property of 4-Methoxyindan-1-ol

Chemical Property:

• PSA: 29.46000
• LogP: 1.67480
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 164.083729621
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

98% ^*data from raw suppliers

4-methoxy-2,3-dihydro-1H-inden-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1CCC2O

Technology Process of 4-Methoxyindan-1-ol

There total 4 articles about 4-Methoxyindan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-methoxylindanone (13336-31-7) → 4-methoxy-2,3-dihydro-1H-inden-1-ol (67199-57-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

C6H4(CH2CH2C(O)O) (119-84-6,1341-36-2) → 4-methoxy-2,3-dihydro-1H-inden-1-ol (67199-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) AlCl₃, (ii) /BRN= 635994/

2: LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1007/BF00906359

Reference yield:

4-hydroxy-2,3-dihydroindan-1-one (40731-98-4) → 4-methoxy-2,3-dihydro-1H-inden-1-ol (67199-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 5 h / 60 °C / Inert atmosphere; Sealed tube

2: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere; Sealed tube

With sodium tetrahydroborate; potassium carbonate; In methanol; acetone;

upstream raw materials:

4-methoxylindanone

C₆H₄(CH₂CH₂C(O)O)

4-hydroxy-2,3-dihydroindan-1-one

Downstream raw materials:

methyl (3S)-3-ethoxy-3-{4-[(4-methoxy-2,3-dihydro-1H-inden-1-yl)oxy]phenyl}propanoate

C₄₅H₅₂N₆O₄

C₃₀H₃₁F₄N₃O₅S

C₄₅H₅₀F₂N₆O₄

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