13336-31-7

Usage

Uses

Used in Comparative Studies:
4-Methoxy-1-indanone is used as a comparative study agent for analyzing the effect of different substituents on the reaction kinetics of various benzo-fused ketones, specifically through the biocatalysed oxidation reaction.
Used in Synthesis of Isomeric Mixtures:
It serves as a starting material in the synthesis of isomeric mixtures of oximes, contributing to the development of diverse chemical compounds.
Used in Organic Chemistry Research:
4-Methoxy-1-indanone is utilized as a starting material in the synthesis of benzo-fused indolizidine and 4-methoxy-1-indanyl compounds, which are significant in organic chemistry research.
Used in Nitration Reactions:
4-METHOXY-1-INDANONE is employed in the synthesis of 4-methoxy-5-nitro-1-indanone through nitration reactions, expanding the range of chemical derivatives available for further study and application.
Used in Pharmaceutical Chemistry:
As one of the reactants, 4-Methoxy-1-indanone is involved in the synthesis of E-2-chloro-8-methyl-3-[(4′-methoxy-1′-indanoyl)-2′-methyliden]-quinoline (IQ), a quinoline derivative with potential applications in pharmaceutical chemistry.

InChI:InChI=1/C10H10O2/c1-12-10-4-2-3-7-8(10)5-6-9(7)11/h2-4H,5-6H2,1H3

Upstream product

• 40731-98-4 4-hydroxy-2,3-dihydroindan-1-one 
• 74-88-4 methyl iodide 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 
• 77-78-1 dimethyl sulfate 
• 67199-57-9 4-methoxy-2,3-dihydro-1H-inden-1-ol 
• 59725-62-1 Benzoic acid 2-(2-chlorocarbonyl-ethyl)-phenyl ester 
• 59725-59-6 3-<2-(benzyloxy)phenyl>propionic acid 
• 59725-61-0 4-(benzyloxy)-1-indanone 
• 67-56-1 methanol 

Downstream Products

• 99545-62-7 4-methoxy-2,2-dimethylindan-1-one 
• 40731-98-4 4-hydroxy-2,3-dihydroindan-1-one 
• 52372-96-0 1-amino-2,3-dihydro-4-methoxy-1H-indene 
• 1116359-18-2 4-methoxy-5-nitro-2,3-dihydro-1H-inden-1-one 
• 157989-07-6 4-methoxy-7-nitro-1-indanone 
• 24633-69-0 3-Methoxy-2-cyanmethyl-benzoylchlorid 
• 163456-61-9 methyl 4-methoxyindan-2-carboxylate 
• 169032-03-5 4-hydroxyindan-2-carboxylic acid 
• 121062-94-0 7-amino-4-hydroxyindanone 

Relevant academic research and scientific papers

Kinetic resolution of racemic benzofused alcohols catalysed by HMFO variants in presence of natural deep eutectic solvents

5-Hydroxymethylfurfural oxidase (HMFO) has demonstrated to be a useful biocatalyst for the selective oxidation of alcohols employing oxygen as mild oxidant with no requirement of expensive organic cofactors. This wild-type HMFO biocatalyst and an engineered thermostable variant have been tested in the kinetic resolution of different benzofused alcohols. The use of natural deep eutectic solvents was also explored in HMFO-catalysed oxidation of alcohols. The oxidation of racemic 1-indanol showed a higher conversion and selectivity in presence of 60% v/v of different NADES, especially for those containing carbohydrates. By choosing properly the biocatalyst and the NADES, good enantioselectivity values can be obtained, demonstrating the advantages of employing these neoteric solvents in biocatalysed processes.

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Arylphosphine oxide and arylphosphine sulfide compounds, and preparation method and application thereof

The invention discloses arylphosphine oxide and arylphosphine sulfide compounds, and a preparation method and an application thereof. The arylphosphine oxide and arylphosphine sulfide compounds can beused as an HIF-2alpha inhibitor to prepare drugs for treating and/or preventing diseases or symptoms related with an anoxic induction factor 2alpha in mammals. The structural formula of the arylphosphine oxide and arylphosphine sulfide compounds is shown in the description.

Methoxy substituted 2-benzylidene-1-indanone derivatives as A1 and/or A2A AR antagonists for the potential treatment of neurological conditions

A prior study reported on hydroxy substituted 2-benzylidene-1-indanone derivatives as A1 and/or A2A antagonists for the potential treatment of neurological conditions. A lead compound (1a) was identified with both A1 and A

Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease

A series of pyridine-linked indanone derivatives were designed and synthesized to discover new small molecules for the treatment of inflammatory bowel disease (IBD). Compounds 5b and 5d exhibited strongest inhibitory activity against TNF-α-induced monocyte adhesion to colon epithelial cells (an in vitro model of colitis). In TNBS (2,4,6-trinitrobenzenesulfonic acid)-induced rat colitis model, oral administration of the compounds 5b and 5d ameliorated colitis with significant recovery in altered expressions of E-cadherin, TNF-α and IL-1β expressions, indicating 5b and 5d as potential agents for therapeutics development against IBD.

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

Bridged Ring compounds As Hepatitis C Virus (HCV) Inhibitors And Pharmaceutical Applications Thereof

Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder.

TETRAZOLINONE COMPOUND AND USE THEREOF

The compound represented by formula (1): wherein R4 and R5 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R6 represents a C1-C4 alkyl group, a C3-C6 cycloalkyl group, or the like; R7, R8, and R9 each represents a hydrogen atom, a halogen atom, or the like; R10 represents a C1-C3 alkyl group, or the like; R13 represents a C1-C3 alkyl group, or the like; and Q represents a phenyl group, or the like; has an excellent control effect on pests.

SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS

Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease.

Non-conventional methodologies in the synthesis of 1-indanones

1-Indanones have been successfully prepared by means of three different non-conventional techniques, namely microwaves, high-intensity ultrasound and a Q-tube reactor. A library of differently substituted 1-indanones has been prepared via one-pot intramolecular Friedel-Crafts acylation and their efficiency and "greenness" have been compared.