3-cyclohexyl-2-(3-ethenylpyrazinyl)-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester

Base Information

Chemical Name:3-cyclohexyl-2-(3-ethenylpyrazinyl)-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester
CAS No.:877278-70-1
Molecular Formula:C₂₅H₂₇N₃O₂
Molecular Weight:401.508
Hs Code.:

Synonyms:3-cyclohexyl-2-(3-ethenylpyrazinyl)-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester

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Chemical Property of 3-cyclohexyl-2-(3-ethenylpyrazinyl)-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester

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Technology Process of 3-cyclohexyl-2-(3-ethenylpyrazinyl)-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester

There total 2 articles about 3-cyclohexyl-2-(3-ethenylpyrazinyl)-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 877278-62-1
C₂₂H₂₃N₃O₂

: 106-95-6
allyl bromide

: 877278-70-1
3-cyclohexyl-2-(3-ethenylpyrazinyl)-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: C₂₂H₂₃N₃O₂; With potassium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.166667h;

allyl bromide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.333333h;

Reference yield:

: 863579-14-0
3-cyclohexyl-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-indole-6-carboxylic acid methyl ester

: 877278-70-1
3-cyclohexyl-2-(3-ethenylpyrazinyl)-1-(2-propenyl)-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; toluene / 80 °C

2: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / 100 °C

3: potassium hydride

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydride; sodium carbonate; lithium chloride; In ethanol; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling / 2: Stille coupling;
DOI:10.1016/j.bmcl.2012.02.063