METHYL 3-CYCLOHEXYL-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDOLE-6-CARBOXYLATE

Base Information

Chemical Name:METHYL 3-CYCLOHEXYL-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDOLE-6-CARBOXYLATE
CAS No.:863579-14-0
Molecular Formula:C22H30BNO4
Molecular Weight:383.295
Hs Code.:

Synonyms:METHYL 3-CYCLOHEXYL-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDOLE-6-CARBOXYLATE

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of METHYL 3-CYCLOHEXYL-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDOLE-6-CARBOXYLATE

Chemical Property:

PSA：60.55000
LogP:4.30140

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of METHYL 3-CYCLOHEXYL-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDOLE-6-CARBOXYLATE

There total 5 articles about METHYL 3-CYCLOHEXYL-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDOLE-6-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 863579-14-0
3-cyclohexyl-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; With triethylamine; In 1,4-dioxane; at 20 ℃; for 3h;

With CyJohnPhos; palladium diacetate; In 1,4-dioxane; at 85 ℃; for 1.5h;
DOI:10.1021/jm0610245

Reference yield: 52.0%

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 73183-34-3
bis(pinacol)diborane

: 863579-14-0
3-cyclohexyl-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: With potassium acetate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 90 ℃; for 16.5h;

Reference yield: 41.0%

: 494799-18-7
methyl 3-cyclohexyl-1H-indole-6-carboxylate

: 73183-34-3
bis(pinacol)diborane

: 863579-14-0
3-cyclohexyl-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: bis(pinacol)diborane; (1,5-cyclooctadiene)(methoxy)iridium(l) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

methyl 3-cyclohexyl-1H-indole-6-carboxylate; In tetrahydrofuran; at 30 ℃; for 3h;