METHYL (1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE

Base Information

Chemical Name:METHYL (1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE
CAS No.:426225-93-6
Molecular Formula:C8H12O3
Molecular Weight:156.181
Hs Code.:
Mol file:426225-93-6.mol

Synonyms:METHYL (1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE

Suppliers and Price of METHYL (1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL-(1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE 95.00%
5MG
$ 502.76

Total 5 raw suppliers

Chemical Property of METHYL (1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE

Chemical Property:

Boiling Point:234.2±23.0 °C(Predicted)
PKA:14.39±0.40(Predicted)
PSA：46.53000
Density:1.143±0.06 g/cm3(Predicted)
LogP:0.34400

Purity/Quality:

97% ^*data from raw suppliers

METHYL-(1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of METHYL (1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE

There total 9 articles about METHYL (1R,4R)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.4%

: 80-73-9
1,3-dimethyl-2-imidazolidinone

: 10581-12-1
tetramethyl ammonium acetate

: 426225-93-6
(1R,4S)-4-hydroxycyclopent-2-en-1-essigsaeure-methylester

Guidance literature:: at 95 ℃; for 13h;
DOI:10.1002/hlca.19890720822

Reference yield: 39.0%

: 660439-53-2
((1R,4R)-4-Trityloxy-cyclopent-2-enyl)-acetic acid methyl ester

: 426225-93-6
(1R,4S)-4-hydroxycyclopent-2-en-1-essigsaeure-methylester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 1.25h;
DOI:10.1021/jm0205604

Reference yield:

: 60410-16-4
(1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate

: 426225-93-6
(1R,4S)-4-hydroxycyclopent-2-en-1-essigsaeure-methylester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / imidazole / tetrahydrofuran / 24 h / 20 °C

2.1: 90 percent / NaOMe; MeOH / 24 h / 20 °C

3.1: DMAP / dimethylformamide / 20 h / 100 °C

4.1: tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5.1: 84 percent / diisopropylethylamine; methanesulfonyl chloride / CH₂Cl₂ / 3 h / 0 °C

6.1: NaH / tetrahydrofuran / 0 - 20 °C

6.2: 72 percent / tetrahydrofuran / 19 h / 75 °C

7.1: 80 percent / LiI / dimethylformamide / 17 h / 130 °C

8.1: 39 percent / p-toluenesulfonic acid / methanol / 1.25 h / 20 °C

With 1H-imidazole; methanol; dmap; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; toluene-4-sulfonic acid; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; lithium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205604