2-Fluoro-1-(2-methoxyphenyl)ethanone

Base Information

• Chemical Name: 2-Fluoro-1-(2-methoxyphenyl)ethanone
• CAS No.: 2967-87-5
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.168
• European Community (EC) Number: 819-172-0
• Nikkaji Number: J1.351.506I
• Mol file: 2967-87-5.mol

Synonyms:2-fluoro-1-(2-methoxyphenyl)ethanone;2967-87-5;Ethanone, 2-fluoro-1-(2-methoxyphenyl)- (9CI);SCHEMBL9141895;2-fluoro-1-(2-methoxyphenyl)ethan-1-one;EN300-1620637

Chemical Property of 2-Fluoro-1-(2-methoxyphenyl)ethanone

Chemical Property:

• Melting Point: 88–89°C
• PSA: 26.30000
• LogP: 1.84740
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 168.05865769
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(=O)CF

Technology Process of 2-Fluoro-1-(2-methoxyphenyl)ethanone

There total 6 articles about 2-Fluoro-1-(2-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

o-methoxystyrene (612-15-7) → 2-fluoro-1-(2-methoxyphenyl)ethanone (2967-87-5)

Guidance literature:

With water; oxygen; acetic acid; Selectfluor; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; at 80 ℃; for 24h; Schlenk technique; Green chemistry;

DOI:10.1021/ol501357w

Reference yield: 74.0%

3-(2-methoxy-phenyl)-3-oxo-propionic acid (76103-94-1) → 2-fluoro-1-(2-methoxyphenyl)ethanone (2967-87-5)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; Selectfluor; In water; at 40 ℃;

DOI:10.1002/adsc.201500282

Reference yield: 63.0%

1-(1-azidovinyl)-2-methoxybenzene (1073483-49-4) → 2-fluoro-1-(2-methoxyphenyl)ethanone (2967-87-5)

Guidance literature:

With water; sodium hydrogencarbonate; Selectfluor; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.6b01691

upstream raw materials:

fluoroacetonitrile

2-bromoanisole

2-Methoxyacetophenone

o-methoxystyrene