(S)-1-(2-naphthyl)propanol

Base Information

• Chemical Name: (S)-1-(2-naphthyl)propanol
• CAS No.: 87241-23-4
• Molecular Formula: C₁₃H₁₄O
• Molecular Weight: 186.254
• Mol file: 87241-23-4.mol

Synonyms:(S)-1-(2-naphthyl)propanol;(S)-1-(naphthalen-2-yl)propan-1-ol

Chemical Property of (S)-1-(2-naphthyl)propanol

Chemical Property:

• PSA: 20.23000
• LogP: 3.28320

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-(2-naphthyl)propanol

There total 11 articles about (S)-1-(2-naphthyl)propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,2-diphenylacetic acid (117-34-0) + 1-(naphthalen-2-yl)propan-1-ol (132154-59-7) → (R)-1-(2-naphthyl)propyl diphenylacetate (1345412-62-5) + (S)-1-(2-naphthyl)propan-1-ol (112576-12-2,132154-59-7,87241-23-4)

Guidance literature:

With (R)-9-methyl-2-phenyl-9-hydro-2-imidazolino[1,2-a]benzimidazole; 2,2-dimethylpropanoic anhydride; In diethyl ether; at 20 ℃; for 12h; optical yield given as %ee; Resolution of racemate;

DOI:10.1039/c1ob05736g

Reference yield: 3.0%

diethylzinc (557-20-0) + β-naphthaldehyde (66-99-9) → 2-Naphthalenemethanol (1592-38-7) + (R)-1-(2-naphthyl)propanol (87241-23-4,132154-59-7,112576-12-2) + (S)-1-(2-naphthyl)propan-1-ol (112576-12-2,132154-59-7,87241-23-4)

Guidance literature:

With (S)-1²-(hydroxymethyl)-1⁴-methyl-1(5,8)-quinolina-4(1,4)-benzenacyclohexaphane; In toluene; at 20 ℃; for 14h; Further Variations:; Reagents; Temperatures; time; Product distribution;

DOI:10.1055/s-2002-25350

Reference yield: 3.0%

diethylzinc (557-20-0) + β-naphthaldehyde (66-99-9) → 2-Naphthalenemethanol (1592-38-7) + (R)-1-(2-naphthyl)propanol (87241-23-4,132154-59-7,112576-12-2) + (S)-1-(2-naphthyl)propan-1-ol (112576-12-2,132154-59-7,87241-23-4)

Guidance literature:

With (S)-1²-(hydroxymethyl)-1⁴-methyl-1(5,8)-quinolina-4(1,4)-benzenacyclohexaphane; In toluene; at 20 ℃; for 14h; Further Variations:; Reagents; Temperatures; time; Product distribution;

DOI:10.1055/s-2002-25350

upstream raw materials:

diethylzinc

β-naphthaldehyde

benzaldehyde

Et₂AlBr

Downstream raw materials:

styrene

2-(1-Methylpropyl)naphthalene

2-(prop-1-en-1-yl)naphthalene

(-)-N,N-dimethyl-4-(1-(naphthalen-2-yl)propyl)aniline

Refernces

• 1、 Slagbrand, Tove,Lundberg, Helena,Adolfsson, Hans. "Ruthenium-catalyzed tandem-isomerization/asymmetric transfer hydrogenation of allylic alcohols". supporting information. p. 16102 - 16106. Retrieved 2015/01/09.
• 2、 Banerjee, Sucharita,Ferrence, Gregory M.,Hitchcock, Shawn R.. "Catalytic asymmetric addition of diethylzinc to aldehydes via chiral, non-racemic β-hydroxy and β-methoxy salicylhydrazone catalysts". scheme or table. p. 837 - 845. Retrieved 2010/11/02.