(R)-2-(1-phenylpropyl)naphthalene

Base Information

• Chemical Name: (R)-2-(1-phenylpropyl)naphthalene
• CAS No.: 1424035-43-7
• Molecular Formula: C₁₉H₁₈
• Molecular Weight: 246.352
• Mol file: 1424035-43-7.mol

Synonyms:(R)-2-(1-phenylpropyl)naphthalene

Chemical Property of (R)-2-(1-phenylpropyl)naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(1-phenylpropyl)naphthalene

There total 5 articles about (R)-2-(1-phenylpropyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

triphenylboroxine (3262-89-3) + (R)-1-(naphthalen-2-yl)propyl pivalate (1424035-73-3) → (R)-2-(1-phenylpropyl)naphthalene (1424035-43-7)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium methylate; In toluene; at 80 ℃; for 3h; Reagent/catalyst; Inert atmosphere; Glovebox;

DOI:10.1021/ja312087x

Reference yield:

triethyl[3-(naphthalen-2-yl)-3-phenylprop-1-yn-1-yl]silane → (R)-2-(1-phenylpropyl)naphthalene (1424035-43-7) + (S)-2-(1-phenylpropyl)naphthalene

Guidance literature:

triethyl[3-(naphthalen-2-yl)-3-phenylprop-1-yn-1-yl]silane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; at 20 ℃; for 336h; Inert atmosphere;

With palladium on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 24h; under 760.051 Torr; Overall yield = 13.3 mg; Inert atmosphere;

DOI:10.1002/chem.201503647

Reference yield:

(R)-1-(2-naphthyl)propanol (87241-23-4,132154-59-7,112576-12-2) → (R)-2-(1-phenylpropyl)naphthalene (1424035-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium methylate / toluene / 3 h / 80 °C / Inert atmosphere; Glovebox

With dmap; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium methylate; triethylamine; In dichloromethane; toluene;

DOI:10.1021/ja312087x

upstream raw materials:

triphenylboroxine

(R)-1-(naphthalen-2-yl)propyl pivalate

(R)-1-(2-naphthyl)propanol

methyl (2-naphthyl)(phenyl)methyl carbonate