2-benzylphenylboronic acid

Base Information

• Chemical Name: 2-benzylphenylboronic acid
• CAS No.: 40276-63-9
• Molecular Formula: C13H13BO2
• Molecular Weight: 212.05212
• Mol file: 40276-63-9.mol

Synonyms:2-benzylphenylboronic acid

Chemical Property of 2-benzylphenylboronic acid

Chemical Property:

• PSA: 40.46000
• LogP: 0.95720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2-Benzylphenyl)boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzylphenylboronic acid

There total 5 articles about 2-benzylphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-benzyl-1-bromobenzene (23450-18-2) → (2-benzylphenyl)boronic acid (40276-63-9)

Guidance literature:

2-benzyl-1-bromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.00666667h; Inert atmosphere;

With Trimethyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/acs.joc.5b00378

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 2-benzyl-1-bromobenzene (23450-18-2) → (2-benzylphenyl)boronic acid (40276-63-9)

Guidance literature:

2-benzyl-1-bromobenzene; With n-butyllithium; In tetrahydrofuran; for 1.5h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; at -78 ℃; for 9h; Inert atmosphere;

DOI:10.1039/c6cc03106d

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (2-benzylphenyl)boronic acid (40276-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / nitrobenzene / 6 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran / 1.5 h / Inert atmosphere

2.2: 9 h / -78 °C / Inert atmosphere

With aluminum (III) chloride; n-butyllithium; In tetrahydrofuran; nitrobenzene;

DOI:10.1039/c6cc03106d

upstream raw materials:

tris(2-benzylphenyl)boroxine

2-benzyl-1-bromobenzene

1-Bromo-2-bromomethyl-benzene

benzene

Downstream raw materials:

6-phenylphenanthridine-2-carbonitrile

C₁₉H₁₂BrN

6-phenylphenanthridine

Refernces

• 1、 Evoniuk, Christopher J.,Hill, Sean P.,Hanson, Kenneth,Alabugin, Igor V.. "Double C-H amination by consecutive SET oxidations". . p. 7138 - 7141. Retrieved 2016/06/09.