Benzeneacetic acid, 4-iodo-α-Methyl

Base Information

• Chemical Name: Benzeneacetic acid, 4-iodo-α-Methyl
• CAS No.: 34645-72-2
• Molecular Formula: C11H13IO2
• Molecular Weight: 276.074
• Mol file: 34645-72-2.mol

Synonyms:Benzeneacetic acid, 4-iodo-α-Methyl;Ethyl 2-(4-iodophenyl)propanoate;2-(4-iodophenyl)propanoic acid

Chemical Property of Benzeneacetic acid, 4-iodo-α-Methyl

Chemical Property:

• Melting Point: 187-190 °C
• Boiling Point: 333.2±25.0 °C(Predicted)
• PKA: 4.24±0.10(Predicted)
• PSA: 37.30000
• Density: 1.767±0.06 g/cm3(Predicted)
• LogP: 2.47930

Purity/Quality:

95% ^*data from raw suppliers

2-(4-Iodophenyl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, 4-iodo-α-Methyl

There total 12 articles about Benzeneacetic acid, 4-iodo-α-Methyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sodium chlorite (7758-19-2) + 4-iodo-α-methylbenzeneacetaldehyde (70991-79-6) + aminosulfonic acid (5329-14-6) → (RS)-2-(4'-iodophenyl)propanoic acid (34645-72-2)

Guidance literature:

With sodium hydroxide; sodium hydrogen sulphite; In water; 1,2-dichloro-ethane;

Reference yield: 94.0%

sodium chlorite (7758-19-2) + 4-iodo-α-methylbenzeneacetaldehyde (70991-79-6) + aminosulfonic acid (5329-14-6) + sodium hydrogensulfite → (RS)-2-(4'-iodophenyl)propanoic acid (34645-72-2)

Guidance literature:

With sodium hydroxide; In water; 1,2-dichloro-ethane;

Reference yield:

2-(4-iodo-phenyl)-propionic acid methyl ester (41073-25-0) → (RS)-2-(4'-iodophenyl)propanoic acid (34645-72-2)

Guidance literature:

2-(4-iodo-phenyl)-propionic acid methyl ester; With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=1;

upstream raw materials:

Diethyl 2-methyl-2-(4-nitrophenyl)malonate

amino-4-phenyl methyl malonate d'ethyle

4-Fluoronitrobenzene

sodium chlorite

Downstream raw materials:

2-(4'-<2-methyl-1-propenyl>phenyl)propanoic acid

2-(4-biphenylyl)propanoic acid

ibuprofen

(S)-(+)-2-(4'-iodophenyl)propanoic acid

Refernces

• 1、 -. "New piperidine derivatives, pharmaceutical compositions and uses thereof". Paragraph 0351; 0352. . Retrieved 2013/06/26.
• 2、 -. "New compounds, pharmaceutical compositions and uses thereof". Page/Page column 35. . Retrieved 2012/09/05.