tert-butyl 2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetate
CAS No.:179524-35-7
Molecular Formula:C₁₉H₂₄N₂O₅S
Molecular Weight:392.476
Hs Code.:
Mol file:179524-35-7.mol

Synonyms:tert-butyl 2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetate

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of tert-butyl 2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetate

There total 9 articles about tert-butyl 2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 179524-34-6
t-Butyl (3-Amino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetate

: 1939-99-7
benzenesulfonyl chloride

: 179524-35-7
t-butyl (3-benzylsufonylamino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetate

Guidance literature:: With pyridine; for 1h;
DOI:10.1016/S0960-894X(97)00257-6

Reference yield:

: 179524-33-5
2-[6-methyl-2-oxo-3-(benzyloxycarbonylamino)-2H-pyridin-1-yl]acetic acid t-butyl ester

: 179524-35-7
t-butyl (3-benzylsufonylamino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / H₂; Pd/C / ethanol

2: collidine

With 2,3,5-trimethyl-pyridine; palladium on activated charcoal; hydrogen; In ethanol;
DOI:10.1016/S0960-894X(02)00129-4

Reference yield:

: 38116-61-9
2-hydroxy-6-methylnicotinic acid

: 179524-35-7
t-butyl (3-benzylsufonylamino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.)DPPA, Et₃N / 1.) dioxane, reflux, 16 h, 2.) dioxane, reflux, 24 h

2: 97 percent / NaH / 1.) from 0 deg C to RT, 2.) RT, 2 h

3: 98 percent / H₂ / Parlman's catalyst / ethanol; H₂O / 2 h / 3102.89 Torr

4: 83 percent / pyridine / 1 h / 0 °C

With pyridine; diphenyl-phosphinic acid; hydrogen; sodium hydride; triethylamine; palladium dihydroxide; In ethanol; water;
DOI:10.1021/jm980368v