tert-butyl 2-(3-(benzyloxycarbonylamino)-6-methyl-2-oxopyridin-1(2H)-yl)acetate

Base Information

• Chemical Name: tert-butyl 2-(3-(benzyloxycarbonylamino)-6-methyl-2-oxopyridin-1(2H)-yl)acetate
• CAS No.: 179524-33-5
• Molecular Formula: C₂₀H₂₄N₂O₅
• Molecular Weight: 372.421
• Mol file: 179524-33-5.mol

Synonyms:tert-butyl 2-(3-(benzyloxycarbonylamino)-6-methyl-2-oxopyridin-1(2H)-yl)acetate

Chemical Property of tert-butyl 2-(3-(benzyloxycarbonylamino)-6-methyl-2-oxopyridin-1(2H)-yl)acetate

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

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Technology Process of tert-butyl 2-(3-(benzyloxycarbonylamino)-6-methyl-2-oxopyridin-1(2H)-yl)acetate

There total 12 articles about tert-butyl 2-(3-(benzyloxycarbonylamino)-6-methyl-2-oxopyridin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bromoacetic acid tert-butyl ester (5292-43-3) + benzyl N-(6-methyl-2-oxo-1,2-dihydro-3-pyridinyl)carbamate (147269-61-2) → 2-[6-methyl-2-oxo-3-(benzyloxycarbonylamino)-2H-pyridin-1-yl]acetic acid t-butyl ester (179524-33-5)

Guidance literature:

With sodium hydride; 1.) from 0 deg C to RT, 2.) RT, 2 h;

DOI:10.1021/jm980368v

Reference yield: 97.0%

bromoacetic acid tert-butyl ester (5292-43-3) + (2-hydroxy-6-methylpyridin-3-yl)carbamic acid benzyl ester (147269-61-2) → 2-[6-methyl-2-oxo-3-(benzyloxycarbonylamino)-2H-pyridin-1-yl]acetic acid t-butyl ester (179524-33-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 2h;

DOI:10.1016/S0960-894X(97)00257-6

Reference yield: 82.0%

→ 2-[6-methyl-2-oxo-3-(benzyloxycarbonylamino)-2H-pyridin-1-yl]acetic acid t-butyl ester (179524-33-5) + t-Butyl (3-Amino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetate (179524-34-6)

Guidance literature:

upstream raw materials:

bromoacetic acid tert-butyl ester

benzyl N-(6-methyl-2-oxo-1,2-dihydro-3-pyridinyl)carbamate

(2-hydroxy-6-methylpyridin-3-yl)carbamic acid benzyl ester

t-Butyl (3-Carboxy-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetate

Downstream raw materials:

2-(3-benzyloxycarbonylamino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

[3-[(benzylsulfonyl)amino]-6-methyl-2-oxo-1,2-dihydropyridyl]acetyl-Ng-nitro-L-argininal ethyl cyclol

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