5-methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride

Base Information

• Chemical Name: 5-methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride
• CAS No.: 51655-71-1
• Molecular Formula: C11H8ClNO2
• Molecular Weight: 221.643
• Hs Code.: 2934999090
• Mol file: 51655-71-1.mol

Synonyms:5-METHYL-2-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE;5-Methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride 97%

Chemical Property of 5-methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride

Chemical Property:

• Vapor Pressure: 5.76E-05mmHg at 25°C
• Melting Point: 135 °C
• Boiling Point: 346.4°C at 760 mmHg
• Flash Point: 163.3°C
• PSA: 43.10000
• Density: 1.278g/cm³
• LogP: 3.02900

Purity/Quality:

98% min ^*data from raw suppliers

5-Methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride

There total 5 articles about 5-methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-2-phenyloxazole-4-carboxylic acid (18735-74-5) → 2-phenyl-5-methyl-4-oxazolecarboxylic acid chloride (51655-71-1)

Guidance literature:

With thionyl chloride;

DOI:10.1039/jr9520001085

Reference yield:

4-acetyl-5-methyl-2-phenyloxazole (2940-19-4) → 2-phenyl-5-methyl-4-oxazolecarboxylic acid chloride (51655-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOBr / dioxane

2: SO₂Cl / dimethylformamide

With sulfuryl dichloride; sodium hypobromide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/ja00855a033

Reference yield:

ethyl 5-methyl-2-phenyloxazole-4-carboxylate (61151-96-0) → 2-phenyl-5-methyl-4-oxazolecarboxylic acid chloride (51655-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / ethanol

2: SOCl₂ / dimethylformamide

With sodium hydroxide; thionyl chloride; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

5-methyl-2-phenyloxazole-4-carboxylic acid

ethyl 5-methyl-2-phenyloxazole-4-carboxylate

2-benzoylamino-3-oxobutyric acid ethyl ester

benzoyl chloride

Downstream raw materials:

5-methyl-2-phenyl-1,3-oxazole-4-carboxaldehyde

(5-methyl-2-phenyloxazol-4-yl)(phenyl)methanone

5-methyl-2-phenyl-oxazole-4-carboxylic acid amide

ethyl 5-methyl-2-phenyloxazole-4-carboxylate

Refernces