18735-74-5

Basic information

• Product Name: 5-METHYL-2-PHENYL-1,3-OXAZOLE-4-CARBOXYLIC ACID
• Synonyms: 5-METHYL-2-PHENYL-1,3-OXAZOLE-4-CARBOXYLIC ACID;IFLAB-BB F2124-0564;5-Methyl-2-phenyl-1,3-oxazole-4-carboxylic acid 97%;5-Methyl-2-phenyloxazole-4-carboxylic acid;5-Methyl-2-phenyl-oxazol-4-carboxylicacid;4-Oxazolecarboxylic acid, 5-Methyl-2-phenyl-;4-Carboxy-5-methyl-2-phenyl-1,3-oxazole, (4-Carboxy-5-methyl-1,3-oxazol-2-yl)benzene;5-Methyl-2-phenyl-1,3-oxazole-4-carboxylicacid97%
• CAS NO: 18735-74-5
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19
• Product Categories: Heterocycles series;Carboxylic Acids;Oxazoles, Isoxazoles & Benzoxazoles;Carboxylic Acids;Oxazoles, Isoxazoles & Benzoxazoles
• Mol File: 18735-74-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 182 °C
• Boiling Point: 400.1 °C at 760 mmHg
• Flash Point: 195.8 °C
• Appearance: /
• Density: 1.273 g/cm³
• Vapor Pressure: 4.04E-07mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 3.03±0.32(Predicted)
• CAS DataBase Reference: 5-METHYL-2-PHENYL-1,3-OXAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-PHENYL-1,3-OXAZOLE-4-CARBOXYLIC ACID(18735-74-5)
• EPA Substance Registry System: 5-METHYL-2-PHENYL-1,3-OXAZOLE-4-CARBOXYLIC ACID(18735-74-5)

Safety Data

• Hazard Codes: Harmful:
• Hazardous Substances Data: 18735-74-5(Hazardous Substances Data)

Usage

Uses

2-Phenyl-5-methyloxazole-4-carboxylic Acid is a building block used to prepare oxazole transthyretin amyloidogenesis inhibitors. It is also used to synthesize inhibitors of HldE kinase as Gram-negative antivirulence drugs.

InChI:InChI=1/C11H9NO3/c1-7-9(11(13)14)12-10(15-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,13,14)/p-1

Upstream product

• 59171-72-1 2-phenyl-oxazole-4-carboxylic acid methyl ester 
• 546-67-8 lead(IV) tetraacetate 
• 64-19-7 acetic acid 
• 37791-41-6 4-ethylidene-2-phenyl-5-oxazolone 
• 1227492-02-5 (4S,5S)-5-methyl-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid 
• 98-88-4 benzoyl chloride 
• 18735-67-6 1-(5-methyl-3-oxy-2-phenyl-oxazol-4-yl)-ethanone; hydrochloride 
• 99990-33-7 (E)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester 
• 105907-17-3 2-benzoylamino-3-chloro-crotonic acid methyl ester 
• 4411-93-2 2-ethylidene-4-oxo-4-phenylbutyric acid 
• 105909-91-9 methyl 2-benzoylamino-3-methylacrylate 
• 61151-90-4 2-benzoylamino-3-oxobutyric acid ethyl ester 
• 99973-53-2 4-(1-chloro-ethylidene)-2-phenyl-4H-oxazol-5-one 
• 495-69-2 Hippuric Acid 

Downstream Products

• 100063-41-0 methyl 5-methyl-2-phenyloxazole-4-carboxylate 
• 138676-18-3 5-ethyl-2-phenyloxazole-4-carboxylic acid 
• 1007123-33-2 ((S)-2,2-dimethyl-1-oxo-1-((S)-2-oxoazepan-3-ylamino)decan-3-yl) 6-(N-(benzyloxy)formamido)-(2S)-2-(5-methyl-2-phenyloxazole-4-carboxamido)hexanoate 
• 52955-65-4 (5-methyl-2-phenyloxazol-4-yl)(phenyl)methanone 
• 57742-59-3 1-(5-methyl-2-phenyl-oxazol-4-yl)-1-phenyl-ethanol 
• 51655-72-2 5-methyl-2-phenyl-oxazole-4-carboxylic acid amide 
• 70170-23-9 5-methyl-2-phenyl-1,3-oxazole-4-carboxaldehyde 

Relevant articles and documents

A mild high yielding synthesis of oxazole-4-carboxylate derivatives

Several 2,5-disubstituted oxazole-4-carboxylates were prepared in high yields from the methyl esters of N-acyl-β-halodehydroaminobutyric acid derivatives by treatment with a 2% solution of DBU in acetonitrile. The scope of this reaction was investigated a

Towards Gram-negative antivirulence drugs: New inhibitors of HldE kinase

Gram-negative bacteria lacking heptoses in their lipopolysaccharide (LPS) display attenuated virulence and increased sensitivity to human serum and to some antibiotics. Thus inhibition of bacterial heptose synthesis represents an attractive target for the development of new antibacterial agents. HldE is a bifunctional enzyme involved in the synthesis of bacterial heptoses. Development of a biochemical assay suitable for high-throughput screening allowed the discovery of inhibitors 1 and 2 of HldE kinase. Study of the structure-activity relationship of this series of inhibitors led to highly potent compounds.

Syntheses of amamistatin fragments and determination of their HDAC and antitumor activity

Amamistatins A and B are natural products found to have anti-proliferative effects against MCF-7, A549, and MKN45 human tumor cell lines (IC50 0.24-0.56 μM). It was proposed that their activity was due to histone deacetylase (HDAC) inhibition m