7-Chloro-2-methylquinoline-4-carboxylic acid

Base Information

Chemical Name:7-Chloro-2-methylquinoline-4-carboxylic acid
CAS No.:59666-15-8
Molecular Formula:C₁₁H₈ClNO₂
Molecular Weight:221.643
Hs Code.:
DSSTox Substance ID:DTXSID10360703
Wikidata:Q82142576

Synonyms:7-CHLORO-2-METHYLQUINOLINE-4-CARBOXYLIC ACID;59666-15-8;CHEMBRDG-BB 4003775;7-chloro-2-methyl-4-quinolinecarboxylic acid;SCHEMBL5760270;DTXSID10360703;MFCD00454150;AKOS010211349;SB70569;BS-38276;CS-0322834;2-methyl-7-chloroquinoline-4-carboxylic acid;F93551;7-CHLORO-2-METHYLQUINOLINE-4-CARBOXYLICACID

Suppliers and Price of 7-Chloro-2-methylquinoline-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 7-Chloro-2-methylquinoline-4-carboxylic acid

Chemical Property:

Vapor Pressure:2.3E-06mmHg at 25°C
Boiling Point:377.3°C at 760 mmHg
Flash Point:182°C
Density:1.406g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:221.0243562
Heavy Atom Count:15
Complexity:259

Purity/Quality:: 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C2C=CC(=CC2=N1)Cl)C(=O)O

Technology Process of 7-Chloro-2-methylquinoline-4-carboxylic acid

There total 2 articles about 7-Chloro-2-methylquinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2E)-N-(3-chlorophenyl)-2-hydroxyiminoacetamide

: 67-64-1
acetone

: C₁₁H₈ClNO₂

: 59666-15-8
7-Chloro-2-methylquinoline-4-carboxylic acid

Guidance literature:: (2E)-N-(3-chlorophenyl)-2-hydroxyiminoacetamide; With sulfuric acid; In water; at 60 - 80 ℃; for 0.5h; Inert atmosphere;

With potassium hydroxide; In water; at 20 ℃; for 0.166667h; Cooling with ice;

acetone; Overall yield = 2.26 g; regioselective reaction; Further stages;
DOI:10.1055/s-0035-1561395

Reference yield:

: 59666-15-8
7-Chloro-2-methylquinoline-4-carboxylic acid

Guidance literature:

Reference yield:

: 59666-15-8
7-Chloro-2-methylquinoline-4-carboxylic acid

: 81735-33-3
C₁₂H₉ClN₄O₂S

Guidance literature:: Multi-step reaction with 2 steps

1: 90.2 percent / SeO₂ / dioxane / 5 h / 100 - 110 °C

2: 98.9 percent / aq. ethanol / 0.5 h / 65 - 70 °C

With selenium(IV) oxide; In 1,4-dioxane; ethanol;
DOI:10.1007/BF00762028