Technology Process of (alphaS)-alpha-[[[Methyl[[2-(1-Methylethyl)-4-thiazolyl]Methyl]aMino]carbonyl]aMino]-4-Morpholinebutanoic acid Methyl ester
There total 2 articles about (alphaS)-alpha-[[[Methyl[[2-(1-Methylethyl)-4-thiazolyl]Methyl]aMino]carbonyl]aMino]-4-Morpholinebutanoic acid Methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride;
In
chloroform; water; acetonitrile;
at 25 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 25 °C
1.2: 7 h / 25 °C
2.1: dichloromethane / 1 h / 25 °C
3.1: sodium cyanoborohydride / water; acetonitrile; chloroform / 12 h / 25 °C
With
sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; chloroform; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: water; lithium hydroxide / tetrahydrofuran / 1 h / 25 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 25 °C
3: hydrogenchloride / 1,4-dioxane / 3 h / 25 °C
4: sodium carbonate / water
5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 14 h / 25 - 65 °C
With
hydrogenchloride; water; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
