154212-60-9

Basic information

• Product Name: 2-Isopropyl-4-(methylaminomethyl)thiazole
• Synonyms: 2-ISOPROPYL-4-(METHYLAMINOMETHYL)THIAZOLE;1-(2-Isopropylthiazol-4-yl)-N-methyl methanamine;2-isopropyl-1,3-thiazol-4-methylmethanamine hydrochloride;2-Isopropyl-4-(Methylaminomethyl)Thiazole(IntermediateOfRitonavir);2-isopropyl-4-(N-methyl)aminomethylthiazole;N-methyl-(2-isopropyl-1,3-thiazol-4-yl)methylamine;4-Thiazolemethanamine, N-methyl-2-(1-methylethyl)-;1-(2-isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine(SALTDATA: 2HCl 0.4H2O 0.01S8)
• CAS NO: 154212-60-9
• Molecular Formula: C₈H₁₄N₂S
• Molecular Weight: 170.28
• EINECS: 414-800-6
• Mol File: 154212-60-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 230.874 °C at 760 mmHg
• Flash Point: 93.429 °C
• Appearance: /
• Density: 1.039 g/cm³
• Vapor Pressure: 0.064mmHg at 25°C
• Refractive Index: 1.523
• PKA: 8.06±0.10(Predicted)
• CAS DataBase Reference: 2-Isopropyl-4-(methylaminomethyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Isopropyl-4-(methylaminomethyl)thiazole(154212-60-9)
• EPA Substance Registry System: 2-Isopropyl-4-(methylaminomethyl)thiazole(154212-60-9)

Safety Data

• Hazard Codes: Xn,N
• Statements: 21/22-38-41-51/53
• Safety Statements: 26-36/37/39-61
• Hazardous Substances Data: 154212-60-9(Hazardous Substances Data)

Usage

General Description

2-Isopropyl-4-(methylaminomethyl)thiazole is a chemical compound belonging to the thiazole class. It is composed of a thiazole ring with an isopropyl group and a methylaminomethyl group attached at different positions. This chemical compound is commonly used in the fragrance industry as it possesses a strong odor and is often found in various perfumes and colognes. It is also utilized in the food industry as a flavoring agent due to its intense and unique aroma. Additionally, it has been studied for its potential use in pharmaceuticals and as an antimicrobial agent due to its biological activities.

InChI:InChI=1/C8H14N2S/c1-6(2)8-10-7(4-9-3)5-11-8/h5-6,9H,4H2,1-3H3

Upstream product

• 619330-29-9 2-isopropyl-N-methyl-1,3-thiazole-4-carboxamide 
• 13515-65-6 thioisobutyramide 
• 534-07-6 1,3-Dichloroacetone 
• 74-89-5 methylamine 
• 3364-78-1 2-chloromethyl-thiazole 
• 65386-28-9 4-(Chloromethyl)-2-isopropylthiazole Hydrochloride 
• 40516-57-2 2-isopropyl-4-chloromethylthiazole 

Downstream Products

• 1004317-52-5 C₃₅H₃₇N₅O₃S 
• 154212-61-0 N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine 
• 154248-99-4 N-((N-methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine methyl ester 
• 908591-25-3 2-isopropyl-4-(((N-methyl)amino)methyl)thiazole hydrochloride 
• 155213-67-5 ritonavir 
• 1004316-93-1 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea 
• 1169870-28-3 C₃₆H₅₃N₇O₅S₂ 
• 1169870-18-1 C₃₉H₅₁N₇O₅S₂ 
• 1004316-96-4 C₂₄H₃₄N₄O₄S 
• 1004316-95-3 C₂₀H₂₅N₃O₄S 
• 1004316-94-2 C₂₀H₂₇N₃O₄S 
• 1169870-16-9 C₁₇H₂₇N₄O₄S^(1-)*K⁽¹⁺⁾ 
• 1051461-56-3 C₃₈H₄₆N₈O₄S₂ 

Relevant articles and documents

A N - methyl -2 - isopropyl -4 - thiazole preparation of method

The present invention provides a N - methyl - 2 - isopropyl - 4 - thiazole preparation of method, relates to the technical field of drug synthesis, solves the problem of the ritonavir intermediate N - methyl - 2 - isopropyl - 4 - thiazole preparation of method the existence of toxicity is relatively large, not friendly to the environment the technical problem. The preparation method comprises the following steps: (1) acylated - cyclization reaction; (2) aromatization - substitution reaction; (3) reduction reaction. The invention provides N - methyl - 2 - isopropyl - 4 - thiazole preparation of method, through to the cheap and easy isobutyryl chloride with cysteine methyl ester hydrochloride as raw materials; - cyclization reaction by acylation, aromatization - substitution reaction, the reduction reaction of the three-step synthesizing the compound; compared with the prior preparation method, has environmental protection of green, easy large-scale industrial production and yield and the like, has good application prospect.

Preparation method for 2-isopropyl-4-(methyl aminomethyl) thiazole hydrochloride

The invention belongs to the field of medical intermediate synthesis, relates to a preparation method for ritonavir intermediate synthesis and particularly relates to a preparation method for 2-isopropyl-4-(methyl aminomethyl) thiazole hydrochloride. Isobutyric acid firstly reacts with thionyl chloride, and then ammonium sulfide and ammonium hydroxide are subjected to sulfo-reaction and aminating reaction, the existing process of using phosphorus pentasulfide for performing sulfo-reaction after acylation is replaced, the heavy smell is prevented from generating in the preparation process to avoid the environmental pollution. According to the invention, 1,3-dihydroxy acetone is adopted for replacing 1,3-dichloroacetone with high price, heavy smell and high pollution, the cost is saved and the preparation is environmentally friendly. According to the preparation method provided by the invention, the process is simple, the yield higher than that of the prior art and the preparation method is suitable for industrial production.

ACID ADDITION SALT OF 2-ISOPROPYL-4-(((N-METHYL)AMINO)METHYL)THIAZOLE AND ITS?USE IN THE PREPARATION OF RITONAVIR

The present invention relates to a novel acid addition salt of 2-Isopropyl-4-(((N-methyl)amino)methyl)thiazole of Formula (I) which is a useful intermediate for preparing HIV protease inhibitors. The present invention further provides a process for preparing ritonavir, a HIV protease inhibitor, using the compound of Formula (I).