2-(4-(tert-butyldimethylsilyloxy)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(tert-butyldimethylsilyloxy)phenyl)-2-methylpropanenitrile
CAS No.:210551-82-9
Molecular Formula:C₁₆H₂₅NOSi
Molecular Weight:275.466
Hs Code.:
Mol file:210551-82-9.mol

Synonyms:2-(4-(tert-butyldimethylsilyloxy)phenyl)-2-methylpropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(tert-butyldimethylsilyloxy)phenyl)-2-methylpropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:: SDS file from LookChem

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Technology Process of 2-(4-(tert-butyldimethylsilyloxy)phenyl)-2-methylpropanenitrile

There total 1 articles about 2-(4-(tert-butyldimethylsilyloxy)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 167263-57-2
4-(tert-butyldimethylsilyloxy)-phenyl-acetonitrile

: 74-88-4
methyl iodide

: 210551-82-9
2-(4-tert-butyldimethylsilyloxyphenyl)-2-methylpropanenitrile

Guidance literature:: Multistep reaction.;
DOI:10.1021/jm0700417

Reference yield:

: 210551-82-9
2-(4-tert-butyldimethylsilyloxyphenyl)-2-methylpropanenitrile

: 55770-61-1
2-(4-Hydroxyphenyl)-2-methylpropionitrile

Guidance literature:: With triethylamine tris(hydrogen fluoride); In acetonitrile; at 23 ℃; for 3h;

Reference yield:

: 210551-82-9
2-(4-tert-butyldimethylsilyloxyphenyl)-2-methylpropanenitrile

: 788825-15-0
tert-butyl 2-methyl-2-(4-phenoxyphenyl)propylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 2.25 h

2: 627 mg / NaHCO₃ / tetrahydrofuran; H₂O / 15 h

3: 98 percent / TBAF / tetrahydrofuran / 1 h / 0 °C

4: 46 percent / Cu(OAc)2; 4 Angstroem molecular sieves; pyridine / iPr₂EtN / CH₂Cl₂ / 24 h / 20 °C

With pyridine; lithium aluminium tetrahydride; copper diacetate; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm0700417