2,2′-[(1S,2S)-(+)-1,2-Cyclohexanediylbis[(E)-(nitriloMethylidyne)]]bis[4-(tert-butyl)-6-(4-MorpholinylMethyl)phenol]

Base Information

• Chemical Name: 2,2′-[(1S,2S)-(+)-1,2-Cyclohexanediylbis[(E)-(nitriloMethylidyne)]]bis[4-(tert-butyl)-6-(4-MorpholinylMethyl)phenol]
• CAS No.: 1189364-85-9
• Molecular Formula: C38H56N4O4
• Molecular Weight: 632.88
• Mol file: 1189364-85-9.mol

Synonyms:Phenol, 2,2'-[(1S,2S)-1,2-cyclohexanediylbis[(E)-nitrilomethylidyne]]bis[4-(1,1-dimethylethyl)-6-(4-morpholinylmethyl)-;6,6'-((1E,1'E)-((1S,2S)-Cyclohexane-1,2-diylbis(azanylylidene))bis(methanylylidene))bis(4-(tert-butyl)-2-(morpholinomethyl)phenol)

Chemical Property of 2,2′-[(1S,2S)-(+)-1,2-Cyclohexanediylbis[(E)-(nitriloMethylidyne)]]bis[4-(tert-butyl)-6-(4-MorpholinylMethyl)phenol]

Chemical Property:

• Melting Point: 132-140°C
• Boiling Point: 729.1±60.0 °C(Predicted)
• PKA: 13.05±0.40(Predicted)
• PSA: 83.14000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 5.52980

Purity/Quality:

99% ^*data from raw suppliers

2,2′-[(1S,2S)-(+)-1,2-Cyclohexanediylbis[(E)-(nitrilomethylidyne)]]bis[4-(tert-butyl)-6-(4-morpholinylmethyl)phenol] 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2′-[(1S,2S)-(+)-1,2-Cyclohexanediylbis[(E)-(nitriloMethylidyne)]]bis[4-(tert-butyl)-6-(4-MorpholinylMethyl)phenol]

There total 8 articles about 2,2′-[(1S,2S)-(+)-1,2-Cyclohexanediylbis[(E)-(nitriloMethylidyne)]]bis[4-(tert-butyl)-6-(4-MorpholinylMethyl)phenol] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) + 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde (252735-68-5) → bis[5'-tert-butyl-3'-(2''-morpholin-4'''-ylmethyl)salicylidene]-(R,R)-1,2-cyclohexanediamine (1189364-85-9,252735-72-1,323193-85-7)

Guidance literature:

In ethanol; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2005.03.117

Reference yield: 74.0%

trans-1,2-Diaminocyclohexane (1121-22-8,1436-59-5,20439-47-8,21436-03-3,41013-43-8,694-83-7) + 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde (252735-68-5) → C38H56N4O4 (1189364-85-9,252735-72-1,323193-85-7)

Guidance literature:

In diethyl ether; ethanol; at 20 ℃; for 24h;

DOI:10.1039/b003436n

Reference yield:

para-tert-butylphenol (98-54-4) → bis[5'-tert-butyl-3'-(2''-morpholin-4'''-ylmethyl)salicylidene]-(R,R)-1,2-cyclohexanediamine (1189364-85-9,252735-72-1,323193-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: SnCl₄; nBu₃N

2.1: HOAc / 3 h / 20 °C

2.2: 58 percent / ethanol / 96 h / Heating

3.1: 99 percent / ethanol / 24 h / 20 °C

With tributyl-amine; tin(IV) chloride; acetic acid; In ethanol;

DOI:10.1021/ol016535u

upstream raw materials:

trans-1,2-Diaminocyclohexane

2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde

N-(ethoxymethyl)morpholine

3-(tert-butyl)benzaldehyde