2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde
• CAS No.: 252735-68-5
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.364
• Mol file: 252735-68-5.mol

Synonyms:2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde

Chemical Property of 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde

There total 4 articles about 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(ethoxymethyl)morpholine (18811-63-7) + 3-(tert-butyl)benzaldehyde (23039-28-3) → 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde (252735-68-5)

Guidance literature:

In acetonitrile; for 72h; Heating;

DOI:10.1039/b003436n

Reference yield: 79.0%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-hydroxy-5-t-butylbenzaldehyde (2725-53-3) → 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde (252735-68-5)

Guidance literature:

morpholine; With acetic acid; at 0 ℃; for 0.25h;

formaldehyd; 2-hydroxy-5-t-butylbenzaldehyde; With acetic acid; Further stages.; Heating;

DOI:10.1021/ac800072y

Reference yield:

para-tert-butylphenol (98-54-4) → 2-Hydroxy-3-(morpholin-4-ylmethyl)-5-tert-butylbenzaldehyde (252735-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: SnCl₄; nBu₃N

2.1: HOAc / 3 h / 20 °C

2.2: 58 percent / ethanol / 96 h / Heating

With tributyl-amine; tin(IV) chloride; acetic acid;

DOI:10.1021/ol016535u

upstream raw materials:

N-(ethoxymethyl)morpholine

3-(tert-butyl)benzaldehyde

morpholine

formaldehyd

Downstream raw materials:

(5-tert-butyl-2-hydroxy-3-(morpholinomethyl)phenyl)(phenyl)methanone

(E)-4-tert-butyl-2-{((2,6-diisopropylphenylimino)methyl)-6-(morpholinomethyl)}phenol

bis[5'-tert-butyl-3'-(2''-morpholin-4'''-ylmethyl)salicylidene]-(R,R)-1,2-cyclohexanediamine

C₄NOH₈CH₂C₆H₂(OH)[C(CH₃)3]CHNC₂H₄NCHC₆H₂(OH)[C(CH₃)3]CH₂C₄NOH₈