N-phenylcyclohexanecarboximidamide

Base Information

• Chemical Name: N-phenylcyclohexanecarboximidamide
• CAS No.: 166985-85-9
• Molecular Formula: C₁₃H₁₈N₂
• Molecular Weight: 202.299
• Mol file: 166985-85-9.mol

Synonyms:N-phenylcyclohexanecarboximidamide

Chemical Property of N-phenylcyclohexanecarboximidamide

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenylcyclohexanecarboximidamide

There total 2 articles about N-phenylcyclohexanecarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

cyclohexane carbonitrile (766-05-2) + aniline (62-53-3) → N-phenylcyclohexanecarboximidamide (166985-85-9)

Guidance literature:

With aluminum (III) chloride; at 120 ℃; for 0.666667h; Air; sealed flask;

DOI:10.1021/ol201807n

Reference yield:

aniline benzenesulfonate (4484-20-2) + cyclohexane carbonitrile (766-05-2) → N-phenylcyclohexanecarboximidamide (166985-85-9)

Guidance literature:

at 190 ℃;

DOI:10.1039/jr9490000449

Reference yield: 95.0%

Phenylpropargyl aldehyde (2579-22-8) + N-phenylcyclohexanecarboximidamide (166985-85-9) → C22H22N2O

Guidance literature:

With 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; sodium carbonate; magnesium triflate; In toluene; at 20 ℃; for 24h; Inert atmosphere; Glovebox; Schlenk technique; Molecular sieve;

DOI:10.1039/c8cc02023j

upstream raw materials:

aniline benzenesulfonate

cyclohexane carbonitrile

aniline

Downstream raw materials:

2-Cyclohexyl-4,5-dihydro-1H-imidazol

2-cyclohexylquinazolin-4(3Η)-one

N-tert-butyl-4-amino-2-cyclohexylquinazoline

2-cyclohexylbenzimidazole

Refernces

• 1、 Huang, Jinbo,He, Yimiao,Wang, Yong,Zhu, Qiang. "Synthesis of benzimidazoles by PIDA-promoted direct C(sp2)-H imidation of N-arylamidines". supporting information. p. 13964 - 13967. Retrieved 2013/01/15.
• 2、 -. "N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors". Page/Page column 47-48. . Retrieved 2008/12/06.