ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE

Base Information

• Chemical Name: ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE
• CAS No.: 545394-60-3
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 545394-60-3.mol

Synonyms:6-tert-Butyl-2-methyl-nicotinic acid ethyl ester;Ethyl 6-(tert-butyl)-2-methylnicotinate;6-tert-Butyl-2-methyl-nicotinsaeure-aethylester;ethyl 6-(tert-butyl)-2-methylpyridine-3-carboxylate;

Chemical Property of ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE

Chemical Property:

• Boiling Point: 180 °C (17 mmHg)
• PSA: 39.19000
• LogP: 2.86420
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Ethyl6-(tert-butyl)-2-methylnicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE

There total 3 articles about ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

ethyl 2-methyl nicotinate (1721-26-2) + L-tert-Leucine (20859-02-3) → 3-(ethoxycarbonyl)-2,5-dimethylpyridine (31931-53-0) + ethyl 6-(tert-butyl)-2-methylnicotinate (545394-60-3)

Guidance literature:

ethyl 2-methyl nicotinate; L-tert-Leucine; With ammonium peroxydisulfate; water; trifluoroacetic acid; In 1,2-dichloro-ethane; at 23 ℃; for 0.0166667h;

With silver nitrate; In 1,2-dichloro-ethane; at 80 ℃; for 24h;

DOI:10.1021/acs.orglett.6b01754

Reference yield:

ethyl 2-methyl nicotinate (1721-26-2) + Trimethylacetic acid (75-98-9) → ethyl 6-(tert-butyl)-2-methylnicotinate (545394-60-3)

Guidance literature:

With ammonium persulfate; aq. sulfuric acid; silver nitrate;

Reference yield:

→ ethyl 6-(tert-butyl)-2-methylnicotinate (545394-60-3)

Guidance literature:

durch trockene Destillation des Silbersalzes im Vakuum;

upstream raw materials:

ethyl 2-methyl nicotinate

Trimethylacetic acid

L-tert-Leucine

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