Pyrazolo[1,5-a]pyrazine, 3-broMo-4,5,6,7-tetrahydro-

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyrazine, 3-broMo-4,5,6,7-tetrahydro-
• CAS No.: 1263378-90-0
• Molecular Formula: C6H8BrN3
• Molecular Weight: 202.054
• Mol file: 1263378-90-0.mol

Synonyms:Pyrazolo[1,5-a]pyrazine, 3-broMo-4,5,6,7-tetrahydro-;3-BroMo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine

Chemical Property of Pyrazolo[1,5-a]pyrazine, 3-broMo-4,5,6,7-tetrahydro-

Chemical Property:

• Boiling Point: 325.8±42.0 °C(Predicted)
• PKA: 7.68±0.20(Predicted)
• PSA: 29.85000
• Density: 1.92±0.1 g/cm3(Predicted)
• LogP: 1.07760
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[1,5-a]pyrazine, 3-broMo-4,5,6,7-tetrahydro-

There total 1 articles about Pyrazolo[1,5-a]pyrazine, 3-broMo-4,5,6,7-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-bromo-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester → 3-bromo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine (1263378-90-0)

Guidance literature:

In acetonitrile; at 300 ℃; under 75007.5 Torr;

DOI:10.1021/acs.orglett.6b00378

Reference yield: 61.0%

3-bromo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine (1263378-90-0) + benzaldehyde (100-52-7) → 5-benzyl-3-bromo-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 25 ℃; for 4h;

Reference yield: 12.0%

iodobenzene (591-50-4) + 3-bromo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine (1263378-90-0) → 3-bromo-5-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine

Guidance literature:

With copper(l) iodide; caesium carbonate; L-proline; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h; Inert atmosphere;