S1RA (hydrochloride)

Base Information

• Chemical Name: S1RA (hydrochloride)
• CAS No.: 1265917-14-3
• Molecular Formula: C20H23N3O2.HCl
• Molecular Weight: 373.88
• Mol file: 1265917-14-3.mol

Synonyms:S1RA (hydrochloride);4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride (1:1);4-(2-(5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy)ethyl)morpholine hydrochloride

Chemical Property of S1RA (hydrochloride)

Chemical Property:

• Storage Temp.: -20°C (des.)
• Solubility.: Soluble in DMSO (up to at least 25 mg/ml)

Purity/Quality:

98% min ^*data from raw suppliers

S1RAhydrochloride >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: S1RA (E-52862, 1265917-14-3) is a potent and selective σ1 antagonist with weak binding at σ2?(IC50?σ1 = 17nM, σ2 = 9300nM).1,2?S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.3?S1RA potentiated μ-opioid antinociception in mice in a σ-dependent manner.4?S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5

Technology Process of S1RA (hydrochloride)

There total 1 articles about S1RA (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (878141-96-9) → 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine hydrochloride (1265917-14-3)

Guidance literature:

With hydrogenchloride; In ethanol;

upstream raw materials:

4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine

Refernces

• 1、 -. "USE OF SIGMA LIGANDS IN BONE CANCER PAIN". Paragraph 0086-0087. . Retrieved 2017/04/14.
• 2、 -. "Use of sigma ligands in opioid-induced hyperalgesia". Page/Page column 27; 28. . Retrieved 2017/11/09.