S1RA

Base Information

• Chemical Name: S1RA
• CAS No.: 878141-96-9
• Molecular Formula: C₂₀H₂₃N₃O₂
• Molecular Weight: 337.422
• Mol file: 878141-96-9.mol

Synonyms:S1RA;4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine;4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine S1RA;S1RA 4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine;S1RA, >=98%;S1RA, 878141-96-9

Chemical Property of S1RA

Chemical Property:

• PSA: 39.52000
• LogP: 2.98280
• Solubility.: ≥10.35 mg/mL in DMSO; ≥12.23 mg/mL in EtOH; ≥56.1 mg/mL in H2O

Purity/Quality:

98% min ^*data from raw suppliers

S1RA >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S1RA

There total 8 articles about S1RA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

→ 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (878141-96-9)

Guidance literature:

Reference yield:

N-(2-chlorethyl)morpholine (3240-94-6) + 5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol (1192140-15-0) → 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (878141-96-9)

Guidance literature:

5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol; With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; Alkaline conditions; Inert atmosphere;

N-(2-chlorethyl)morpholine; In N,N-dimethyl-formamide; Inert atmosphere; Heating; Alkaline conditions;

DOI:10.1021/jm3007323

Reference yield:

4-[2-(5-methyl-1H-pyrazol-3-yloxy)ethyl]morpholine (1392755-91-7) + naphthalene-2-boronic acid (32316-92-0) → 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (878141-96-9) + 4-{2-[3-methyl-1-(naphthalen-2-yl)-1H-pyrazol-5-yloxy]ethyl}morpholine (1392760-52-9)

Guidance literature:

With pyridine; copper(II) acetate monohydrate; In dichloromethane; at 20 ℃; Molecular sieve;

DOI:10.1021/jm3007323

upstream raw materials:

tert-butyl 5-methyl-3-(2-morpholinoethoxy)-1H-pyrazole-1-carboxylate

4-[2-(5-methyl-1H-pyrazol-3-yloxy)ethyl]morpholine

naphthalene-2-boronic acid

2-naphthylhydrazine hydrochloride

Downstream raw materials:

4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine hydrochloride

Refernces

• 1、 -. "SIGMA RECEPTOR INHIBITORS". Page/Page column 54. . Retrieved 2008/06/13.