6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid

Base Information

• Chemical Name: 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid
• CAS No.: 1159831-86-3
• Molecular Formula: C₇H₄BrN₃O₂
• Molecular Weight: 242.032
• Hs Code.: 2933990090
• Mol file: 1159831-86-3.mol

Synonyms:6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid

Chemical Property of 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid

Chemical Property:

• PKA: -2.95±0.41(Predicted)
• PSA: 67.49000
• Density: 2.09±0.1 g/cm3(Predicted)
• LogP: 1.19000
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid

There total 1 articles about 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 6-bromo-[ 1,2 ,4]triazolo[4,3-a]pyridine-3-carboxylate → 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (1159831-86-3)

Guidance literature:

With methanol; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

(3aR,6aS)-5-(2-(trifluoromethyl)phenyl)octahydrocyclopenta[c]pyrrole hydrochloride + 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (1159831-86-3) → (6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-((3aR,6aS)-5-(2-(trifluoromethyl)phenyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

6-bromo-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (1159831-86-3) → 3-{[(3aR,6aS)-5-[2-(trifluoromethyl)phenyl]octahydrocyclopenta[c]pyrrol-2-yl]carbonyl}[1,2,4]triazolo[4,3-a]pyridine-6-sulfonyl chloride

Guidance literature:

Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N-ethyl-N,N-diisopropylamine / 16 h / 110 °C

3: N-chloro-succinimide; acetic acid / water / 3 h

With N-chloro-succinimide; palladium diacetate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; N,N-dimethyl-formamide;