2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidin-4-amine

Base Information

• Chemical Name: 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidin-4-amine
• CAS No.: 1032903-48-2
• Molecular Formula: C₁₄H₁₆ClN₃O₂S
• Molecular Weight: 325.819
• Mol file: 1032903-48-2.mol

Synonyms:2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidin-4-amine

Chemical Property of 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidin-4-amine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

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SDS file from LookChem

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Technology Process of 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidin-4-amine

There total 2 articles about 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

→ 2-chloro-5-methyl-N-[2-(propan-2-ylsulfonyl)phenyl]pyrimidin-4-amine (1032903-48-2)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

In dimethyl sulfoxide; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 65.0%

2,6-dichloro-5-methylpyrimidine (1780-31-0) + 1-amino-2-(isopropylsulphonyl)benzene (76697-50-2) → 2-chloro-5-methyl-N-[2-(propan-2-ylsulfonyl)phenyl]pyrimidin-4-amine (1032903-48-2)

Guidance literature:

1-amino-2-(isopropylsulphonyl)benzene; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

2,6-dichloro-5-methylpyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2017.08.035

Reference yield: 66.0%

2-chloro-5-methyl-N-[2-(propan-2-ylsulfonyl)phenyl]pyrimidin-4-amine (1032903-48-2) + 4-fluoro-2-methoxy-5-nitro-phenylamine (1075705-01-9) → N2-(4-fluoro-2-methoxy-5-nitrophenyl)-N4-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine

Guidance literature:

With toluene-4-sulfonic acid; In pentan-1-ol; at 115 ℃; for 5h;

DOI:10.1016/j.ejmech.2017.08.035

upstream raw materials:

2,6-dichloro-5-methylpyrimidine

1-amino-2-(isopropylsulphonyl)benzene

Downstream raw materials:

N₂-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

N₂-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine

2-(4-(5-isopropoxy-4-((4-((2-(isopropylsulfonyl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)-2-methylphenyl)piperidin-1-yl)ethanol

N₂-(2-isopropoxy-4-(1-(2-methoxyethyl)piperidin-4-yl)-5-methylphenyl)-N₄-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine

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