4-fluoro-2-Methoxy-5-nitroaniline

Base Information

• Chemical Name: 4-fluoro-2-Methoxy-5-nitroaniline
• CAS No.: 1075705-01-9
• Molecular Formula: C7H7FN2O3
• Molecular Weight: 186.143
• Hs Code.: 2922299090
• Mol file: 1075705-01-9.mol

Synonyms:4-fluoro-2-Methoxy-5-nitroaniline;2-Amino-5-fluoro-4-nitroanisole, 4-Fluoro-5-nitro-o-anisidine;4-Fluoro-2-Methoxy-5-nitrobenzenaMine;Benzenamine, 4-fluoro-2-methoxy-5-nitro-;4-fluoro-2-methoxy-5-nitrophenylamine

Chemical Property of 4-fluoro-2-Methoxy-5-nitroaniline

Chemical Property:

• Melting Point: 130 °C
• Boiling Point: 354.8±37.0 °C(Predicted)
• PKA: 2.31±0.10(Predicted)
• PSA: 81.07000
• Density: 1.412±0.06 g/cm3(Predicted)
• LogP: 2.42910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ,99% , ^*data from raw suppliers

4-Fluoro-2-methoxy-5-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Fluoro-2-methoxy-5-nitroaniline is used as a reagent for preparing the anticancer drug Mereletinib.

Technology Process of 4-fluoro-2-Methoxy-5-nitroaniline

There total 9 articles about 4-fluoro-2-Methoxy-5-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(4-fluoro-2-methoxy-5-nitro-phenyl)acetamide → 4-fluoro-2-methoxy-5-nitro-phenylamine (1075705-01-9)

Guidance literature:

N-(4-fluoro-2-methoxy-5-nitro-phenyl)acetamide; With hydrogenchloride; water; In ethanol; at 83 ℃; for 5h;

With sodium hydrogencarbonate; In tert-butyl methyl ether; water;

DOI:10.1021/acs.oprd.0c00254

Reference yield: 95.0%

4-fluoro-2-methoxyaniline (450-91-9) → 4-fluoro-2-methoxy-5-nitro-phenylamine (1075705-01-9)

Guidance literature:

With sulfuric acid; potassium nitrate; at 0 - 5 ℃; for 2h; Inert atmosphere;

Reference yield: 87.6%

sodium methylate (124-41-4) + 5-amino-2,4-difluoronitrobenzene (123344-02-5) → 4-fluoro-2-methoxy-5-nitro-phenylamine (1075705-01-9)

Guidance literature:

In methanol; at 20 ℃; for 48h;

upstream raw materials:

4-fluoro-2-methoxyaniline

4-fluoro-2-methoxy-1-nitrobenzene

sodium methylate

5-amino-2,4-difluoronitrobenzene

Downstream raw materials:

C₂₆H₃₃ClN₇O₅P

C₂₆H₃₅ClN₇O₃P

C₂₃H₂₉ClN₇O₄P

(2-((5-chloro-2-((4-fluoro-2-methoxy-5-nitrophenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Refernces

• 1、 Zhu, Guoqing,Wang, Xingyan,Wang, Feng,Mao, Yongjun,Wang, Han. "New and Convergent Synthesis of Osimertinib". . p. 2898 - 2901. Retrieved 2017.
• 2、 Alivertis, Dimitrios,Skobridis, Konstantinos,Voulgari, Pinelopi. "Improvements in the Synthesis of the Third-Generation EGFR Inhibitor Osimertinib". . . Retrieved 2021/10/19.
• 3、 -. "Synthesis method of osimertinib intermediate". Paragraph 0045; 0048-0050; 0053-0055; 0060; 0063-0065; 0068. . Retrieved 2021/02/10.