2-Bromo-4-tert-butyl-1-iodo-benzene

Base Information

• Chemical Name: 2-Bromo-4-tert-butyl-1-iodo-benzene
• CAS No.: 860435-39-8
• Molecular Formula: C10H12BrI
• Molecular Weight: 339.014
• Mol file: 860435-39-8.mol

Synonyms:2-Bromo-4-tert-butyl-1-iodo-benzene

Chemical Property of 2-Bromo-4-tert-butyl-1-iodo-benzene

Chemical Property:

• Boiling Point: 282.0±28.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.744±0.06 g/cm3(Predicted)
• LogP: 4.35120

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4-(tert-butyl)-1-iodobenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-tert-butyl-1-iodo-benzene

There total 2 articles about 2-Bromo-4-tert-butyl-1-iodo-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromo-4-tert-butylaniline (103273-01-4) → 2-bromo-4-tert-butyl-1-iodobenzene (860435-39-8)

Guidance literature:

2-bromo-4-tert-butylaniline; With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 0 - 5 ℃; for 0.5h;

With potassium iodide; In water; acetonitrile; at 20 ℃;

DOI:10.1016/j.tetlet.2012.07.093

Reference yield:

4-tert-Butylaniline (769-92-6) → 2-bromo-4-tert-butyl-1-iodobenzene (860435-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 64 percent / Bu₄NBr₃ / dimethylformamide; H₂O / 0.17 h / 0 - 5 °C

2.1: aq. H₂SO₄; NaNO₂ / 2 h / 10 °C

2.2: 79 percent / aq. KI / 6.33 h

With sulfuric acid; tetra-N-butylammonium tribromide; sodium nitrite; In water; N,N-dimethyl-formamide; 2.2: Sandmeyer reaction;

DOI:10.1021/ja042762q

Reference yield: 93.0%

2-bromo-4-tert-butyl-1-iodobenzene (860435-39-8) + tris-iso-propylsilyl acetylene (89343-06-6) → 3-bromo-4-[(triisopropylsilyl)ethynyl]-tert-butylbenzene

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jacs.1c04880

upstream raw materials:

2-bromo-4-tert-butylaniline

4-tert-Butylaniline

Downstream raw materials:

2-(2-bromo-4-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2,2'-dibromo-4-tert-butyl-[1,1';4',1'';4'',1''']quaterphenyl

C₆₆H₆₀

bis(2-bromo-4-(tert-butyl)phenyl)acetylene

Refernces

• 1、 -. "POLYCYCLIC AROMATIC COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICES USING THE SAME". Paragraph 0123-0124. . Retrieved 2020/06/29.
• 2、 Lv, Jun,Liu, Qiancai,Tang, Jie,Perdih, Franc,Kranjc, Kristof. "A facile synthesis of indolo[3,2,1-jk]carbazoles via palladium-catalyzed intramolecular cyclization". supporting information. p. 5248 - 5252. Retrieved 2012/10/30.