tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate
• CAS No.: 1367126-89-3
• Molecular Formula: C14H19Cl2N3O2
• Molecular Weight: 332.22556
• Hs Code.: 2933990090
• Mol file: 1367126-89-3.mol

Synonyms:tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate

Chemical Property:

• PSA: 45.67000
• LogP: 3.44840
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) + 4-nitro-2,6-dichloro-pyridine (25194-01-8) → tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate (1367126-89-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1355052-34-4) + tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate (1367126-89-3) → C26H27ClFN3O3 (1367126-91-7)

Guidance literature:

With tetrabutyl ammonium fluoride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; at 70 ℃;

Reference yield:

tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate (1367126-89-3) + 4-fluoroboronic acid (1765-93-1) → C20H23ClFN3O2

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 - 90 ℃; for 1h;

upstream raw materials:

1-t-Butoxycarbonylpiperazine

4-nitro-2,6-dichloro-pyridine

Downstream raw materials:

C₂₆H₂₇ClFN₃O₃

C₂₈H₃₀FN₃O₃

C₂₈H₃₂FN₃O₅

C₂₅H₂₆ClFN₄O₂