(17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol

Base Information Edit

Chemical Name:(17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol
CAS No.:122566-22-7
Molecular Formula:C28H40O5
Molecular Weight:456.623
Hs Code.:
Mol file:122566-22-7.mol

Synonyms:(17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol;(17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol (Mixture of DiasteroMers)

Suppliers and Price of (17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol(MixtureofDiasteromers)
50 mg
$ 650.00

Total 2 raw suppliers

Chemical Property of (17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol Edit

Chemical Property:

Boiling Point:607.7±55.0 °C(Predicted)
PKA:14.20±0.60(Predicted)
PSA：57.15000
Density:1.20±0.1 g/cm3(Predicted)
LogP:5.85080

Purity/Quality:

98% HPLC ^*data from raw suppliers

(17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol(MixtureofDiasteromers) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Like 17β-Estradiol (E888000) derivative, (17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol can be used in the preparation of Δ6-estrogens.

Technology Process of (17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol

There total 4 articles about (17β)-3,17-Bis[(tetrahydro-2H-pyran-2-yl)oxy]-estra-1,3,5(10)-trien-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3589-91-1
3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5(10)-triene

: 122566-22-7
(8R,9S,13S,14S,17S)-13-Methyl-3,17-bis-(tetrahydro-pyran-2-yloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-ol

Guidance literature:: 3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5(10)-triene; With n-butyllithium; potassium tert-butylate; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

With Trimethyl borate; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

With dihydrogen peroxide; In tetrahydrofuran; hexane; water; at 20 ℃; for 1h;
DOI:10.1021/jo990641g

Reference yield:

: 50-28-2
estradiol

: 122566-22-7
(8R,9S,13S,14S,17S)-13-Methyl-3,17-bis-(tetrahydro-pyran-2-yloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 3 h / Heating

2.1: LDA; t-BuOK / hexane; tetrahydrofuran / 3.5 h / -78 °C

2.2: (MeO)3B / hexane; tetrahydrofuran / 2 h

2.3: aq. H₂O₂ / hexane; tetrahydrofuran / 1 h / 20 °C

With potassium tert-butylate; pyridinium p-toluenesulfonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja017344p