Z-D-LEU-OSU

Base Information

• Chemical Name: Z-D-LEU-OSU
• CAS No.: 65581-25-1
• Molecular Formula: C18H22N2O6
• Molecular Weight: 362.38
• Hs Code.: 2925190090

Synonyms:Z-D-LEUCINE HYDROXYSUCCINIMIDE ESTER;Z-D-LEUCINE-N-HYDROXYSUCCINIMIDE ESTER;Z-D-LEUCINE-OSU;Z-D-LEU-OSU;BENZYLOXYCARBONYL-D-LEUCINE N-HYDROXYSUCCINIMIDE ESTER;NALPHA-Benzyloxycarbonyl-D-leucine N-hydroxysuccinimide ester;N-alpha-Benzyloxycarbonyl-D-leucine succinimidyl ester;Z-D-LEUCINE HYDROXYSUCCINIMIDESTER

Chemical Property of Z-D-LEU-OSU

Chemical Property:

• PSA: 102.01000
• LogP: 2.26350
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Z-D-leucine-N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-D-LEU-OSU

There total 1 articles about Z-D-LEU-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Z-D-Leu-OH (28862-79-5) → Z-D-Leu-OSu (65581-25-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1021/jm00110a013

Reference yield: 80.0%

Z-D-Leu-OSu (65581-25-1) + 2-[2-(2-Amino-propionylamino)-propionylamino]-propionic acid benzyl ester (102674-83-9) → Z-D-Leu-DL-Ala-DL-Ala-DL-Ala-OBzl (135112-53-7)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

Reference yield:

(R)-leucine methyl ester hydrochloride (5845-53-4,6322-53-8,7517-19-3) + Z-D-Leu-OSu (65581-25-1) → Cbz-D-Leu-D-Leu-OMe

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.tetasy.2005.10.042

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Z-D-Leu-OH

Downstream raw materials:

Z-D-Leu-DL-Ala-DL-Ala-DL-Ala-OBzl

(R)-(-)-1-carbobenzoxy-5-isobutyl-2-iminohydantoin

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