1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol

Base Information

Chemical Name:1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol
CAS No.:301353-96-8
Molecular Formula:C₂₁H₁₈Br₂N₂O
Molecular Weight:474.195
Hs Code.:2933990090
European Community (EC) Number:685-988-7
UNII:77ZWJ3QXR9
DSSTox Substance ID:DTXSID70385472
Nikkaji Number:J2.855.551B
Wikipedia:P7C3
Wikidata:Q7117948
ChEMBL ID:CHEMBL2442630
Mol file:301353-96-8.mol

Synonyms:P7C3;301353-96-8;1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol;1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol;1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol;MFCD00572918;3,6-Dibromo-alpha-[(phenylamino)methyl]-9H-carbazole-9-ethanol;77ZWJ3QXR9;Oprea1_535378;Oprea1_634683;SCHEMBL410147;CHEMBL2442630;DTXSID70385472;EX-A372;HMS3886P19;P7C-3;BCP09423;STK835004;AKOS000630504;AKOS016344050;CCG-269486;CS-5759;P7C3, >=98% (HPLC);NCGC00263551-06;AC-32893;AS-19957;BP162788;HY-15976;BB 0255098;EU-0002979;S7968;SR-01000414355;J-017798;Q7117948;SR-01000414355-1;1-Anilino-3-(3,6-dibromo-9H-carbazol-9-yl)-2-propanol;3,6-Dibromo-?-[(phenylamino)methyl]-9H-carbazole-9-ethanol;9H-Carbazole-9-ethanol, 3,6-dibromo-alpha-[(phenylamino)methyl]-;3,6-DIBROMO-.ALPHA.-((PHENYLAMINO)METHYL)-9H-CARBAZOLE-9-ETHANOL;9H-CARBAZOLE-9-ETHANOL, 3,6-DIBROMO-.ALPHA.-((PHENYLAMINO)METHYL)-

Suppliers and Price of 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
P7C3
10mg
$ 466.00

TRC
P7C3
25mg
$ 305.00

Tocris
P7C3 ≥99%(HPLC)
25
$ 411.00

Tocris
P7C3 ≥99%(HPLC)
5
$ 109.00

Sigma-Aldrich
P7C3 ≥98% (HPLC)
25mg
$ 471.00

Sigma-Aldrich
P7C3 ≥98% (HPLC)
5mg
$ 119.00

Matrix Scientific
1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol
500mg
$ 350.00

Matrix Scientific
1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol
1g
$ 538.00

DC Chemicals
P7C3 >98%
100 mg
$ 375.00

DC Chemicals
P7C3 >98%
250 mg
$ 750.00

Total 30 raw suppliers

Chemical Property of 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol

Chemical Property:

Boiling Point:656.4±55.0 °C(Predicted)
PKA:13.91±0.20(Predicted)
PSA：37.19000
Density:1.61±0.1 g/cm3(Predicted)
LogP:5.86550
Storage Temp.:2-8°C
Solubility.:DMSO: soluble34mg/mL
XLogP3:5.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:473.97654
Heavy Atom Count:26
Complexity:433

Purity/Quality:

99%, ^*data from raw suppliers

P7C3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25-41
Safety Statements: 26-39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O
Description P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus. At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury. While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.
Uses P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.

Technology Process of 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol

There total 1 articles about 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: