benzo[d]thiazol-2-amine

Base Information

• Chemical Name: benzo[d]thiazol-2-amine
• CAS No.: 102337-98-4
• Molecular Formula: C7H6N2S
• Molecular Weight: 150.20094
• Mol file: 102337-98-4.mol

Synonyms:

Chemical Property of benzo[d]thiazol-2-amine

Chemical Property:

• PSA: 67.88000
• LogP: 1.80860

Purity/Quality:

98%min ^*data from raw suppliers

Benzothiazol-2-ylamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzo[d]thiazol-2-amine

There total 89 articles about benzo[d]thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + thiourea (17356-08-0) → 2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5)

Guidance literature:

With dihydrogen peroxide; iodine; toluene-4-sulfonic acid; In acetonitrile; at 75 ℃; for 24h;

DOI:10.1016/j.bmcl.2014.04.082

Reference yield: 95.6%

monophenylthiourea (103-85-5) → 2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5)

Guidance literature:

With thionyl chloride; at 50 - 55 ℃; for 4h;

Reference yield: 95.0%

bromobenzene (108-86-1,52753-63-6) + 2-iodophenylisothiourea → 2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5) + N-phenyl-2-benzothiazolamine (1843-21-6)

Guidance literature:

With 1,10-Phenanthroline; copper(II) acetate monohydrate; caesium carbonate; In dimethyl sulfoxide; Heating;

DOI:10.1039/c8ob02018c

upstream raw materials:

1,3-Benzothiazole

2-chlorobenzo[d][1,3]thiazole

2-thioxo-3H-1,3-benzothiazole

2-nitrophenyl thiocyanate

Downstream raw materials:

N-(1,3-benzothiazol-2-yl)-3-oxobutanamide

3-butyl-3H-benzothiazol-2-one-imine

bis-(3-methyl-benzothiazol-2-yl)-azamethinium ; toluene-4-sulfonate

6-chloro-pyridine-3-sulfonic acid benzothiazol-2-ylamide

Refernces

• 1、 Boddapati, S. N. Murthy,Kurmarayuni, Chandra Mohan,Mutchu, Baby Ramana,Tamminana, Ramana,Bollikolla, Hari Babu. "Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: A novel approach". . p. 6889 - 6894. Retrieved 2018.
• 2、 Mistry, Bhupendra M.,Patel, Rahul V.,Keum, Young-Soo,Kim, Doo Hwan. "Chrysin-benzothiazole conjugates as antioxidant and anticancer agents". . p. 5561 - 5565. Retrieved 2015.
• 3、 Chen, Xiran,Fu, Lianrong,Hao, Xin-Qi,Shi, Linlin,Song, Mao-Ping,Zhu, Xinju,Zhu, Yu-Shen. "Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles". . . Retrieved 2021.
• 4、 Nemakal, Manjunatha,Aralekallu, Shambhulinga,Mohammed, Imadadulla,Pari, Malathesh,Venugopala Reddy,Sannegowda, Lokesh Koodlur. "Nanomolar detection of 4-aminophenol using amperometric sensor based on a novel phthalocyanine". . p. 342 - 353. Retrieved 2019.
• 5、 Mor, Satbir,Mohil, Rajni,Nagoria, Savita,Kumar, Ashwani,Lal, Kashmiri,Kumar, Devinder,Singh, Virender. "Regioselective Synthesis, Antimicrobial Evaluation and QSAR Studies of Some 3-Aryl-1-heteroarylindeno[1,2-c]pyrazol-4(1H)-ones". . p. 1327 - 1341. Retrieved 2017.
• 6、 Dhar S. Yadav, Lal,Krishna Pal Singh, Rana,Singh, Manjula. "Visible-light photoredox catalytic approach for the direct synthesis of 2-aminobenzothiazoles from anilines". . . Retrieved 2020.
• 7、 Kondraganti, Lakshmi,Tamminana, Ramana,Nathani, Srinivasa Rao,Babu, Manabolu Surendra,Ramachandran, Dittakavi. "Cobalt-catalyzed domino C-N cross-coupling reaction between phenyl(2-halo)isothiourea and aryl halide". . p. 559 - 568. Retrieved 2021.
• 8、 Bala, Renu,Kumari, Poonam,Sood, Sumit,Kumar, Vinod,Singh, Nasib,Singh, Karan. "Phthaloyl Dichloride–DMF Mediated Synthesis of Benzothiazole-based 4-Formylpyrazole Derivatives: Studies on Their Antimicrobial and Antioxidant Activities". . p. 2507 - 2515. Retrieved 2018.
• 9、 Naeimi, Hossein,Heidarnezhad, Arash. "Efficient and facile protocol for one-pot synthesis of 2-amino-substituted benzothiazoles catalyzed by nano-BF3/SiO2 under mild conditions". . p. 7855 - 7868. Retrieved 2016.
• 10、 El-Sayed, Amira A,Atta-Allah, Saad R,Hemdan, Magdy M. "Utility of 3-(thiophen-2-yl)prop-2-enoyl isothiocyanate in heterocyclic synthesis". . p. 307 - 312. Retrieved 2019.