3-Chloro-5-(6-chloro-2-fluoro-3-methylphenoxy)benzonitrile

Base Information

Chemical Name:3-Chloro-5-(6-chloro-2-fluoro-3-methylphenoxy)benzonitrile
CAS No.:1089178-82-4
Molecular Formula:C₁₄H₈Cl₂FNO
Molecular Weight:296.128
Hs Code.:
Mol file:1089178-82-4.mol

Synonyms:3-Chloro-5-(6-chloro-2-fluoro-3-methylphenoxy)benzonitrile

Suppliers and Price of 3-Chloro-5-(6-chloro-2-fluoro-3-methylphenoxy)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Chloro-5-(6-chloro-2-fluoro-3-methylphenoxy)benzonitrile

Chemical Property:

Purity/Quality:: ≥99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Chloro-5-(6-chloro-2-fluoro-3-methylphenoxy)benzonitrile

There total 10 articles about 3-Chloro-5-(6-chloro-2-fluoro-3-methylphenoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1093260-77-5
3-[(6-amino-2-fluoro-3-methylphenyl)oxy]-5-chlorobenzonitrile

: 1089178-82-4
3-chloro-5-[(6-chloro-2-fluoro-3-methylphenyl)oxy]benzonitrile

Guidance literature:: With tert.-butylnitrite; copper dichloride; In acetonitrile; at 50 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm301294g

Reference yield:

: 327056-73-5
3-fluoro-5-chlorobenzonitrile

: 261762-91-8
6-chloro-2-fluoro-3-methylphenol

: 1089178-82-4
3-chloro-5-[(6-chloro-2-fluoro-3-methylphenyl)oxy]benzonitrile

Guidance literature:: With potassium carbonate; caesium carbonate; In ISOPROPYLAMIDE; at 120 ℃; for 5.5h;

Reference yield:

: 473923-97-6
3-chloro-5-hydroxybenzonitrile

: 1089178-82-4
3-chloro-5-[(6-chloro-2-fluoro-3-methylphenyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / Reflux

4.1: copper(I) oxide / acetonitrile / 2 h / Reflux

5.1: sodium dithionite; water / tetrahydrofuran / 1 h

6.1: copper dichloride; tert.-butylnitrite / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

With copper(I) oxide; tert.-butylnitrite; sodium dithionite; water; sodium hydride; trifluoroacetic acid; copper dichloride; In tetrahydrofuran; dichloromethane; acetonitrile; mineral oil;
DOI:10.1021/jm301294g