N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate

Base Information

• Chemical Name: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate
• CAS No.: 1093255-32-3
• Molecular Formula: C₂HF₃O₂*C₁₈H₁₁Cl₂FN₄O₂
• Molecular Weight: 519.239
• Mol file: 1093255-32-3.mol

Synonyms:N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate

Chemical Property of N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate

There total 11 articles about N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide (1093255-30-1) → N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate (1093255-32-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield: 60.0%

N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide (1093255-30-1) + trifluoroacetic acid (76-05-1) → N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate (1093255-32-3)

Guidance literature:

In dichloromethane; for 2.5h;

DOI:10.1021/jm301294g

Reference yield:

3-chloro-5-[(2-fluoro-3-methyl-6-nitrophenyl)oxy]benzonitrile (1093260-75-3) → N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate (1093255-32-3)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium dithionite; water / tetrahydrofuran / 1 h

2: copper dichloride; tert.-butylnitrite / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 85 °C

4: ammonia / dichloromethane; methanol / 2 h

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

6: dichloromethane / 2.5 h

With N-Bromosuccinimide; tert.-butylnitrite; sodium dithionite; 2,2'-azobis(isobutyronitrile); ammonia; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; copper dichloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm301294g

upstream raw materials:

3-chloro-5-[(2-fluoro-3-methyl-6-nitrophenyl)oxy]benzonitrile

3-[(6-amino-2-fluoro-3-methylphenyl)oxy]-5-chlorobenzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-methylphenyl)oxy]benzonitrile

3-{[3-(bromomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile