N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane

Base Information

• Chemical Name: N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane
• CAS No.: 1250998-93-6
• Molecular Formula: C14H24INO3
• Molecular Weight: 381.24973
• Hs Code.: 2934999090
• Mol file: 1250998-93-6.mol

Synonyms:N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane;3-(Iodomethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

Chemical Property of N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane

Chemical Property:

• Boiling Point: 416.8±30.0 °C(Predicted)
• PKA: -0.93±0.40(Predicted)
• PSA: 38.77000
• Density: 1.46
• LogP: 3.16550

Purity/Quality:

98%Min ^*data from raw suppliers

tert-Butyl3-(Iodomethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane

There total 1 articles about N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl 4-(hydroxymethyl)-4-(prop-2-en-1-yl)piperidine-1-carboxylate (236406-37-4) → C14H24INO3 (1250998-93-6)

Guidance literature:

With iodine; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1039/d1sc03615g

Reference yield:

C14H24INO3 (1250998-93-6) → C14H26N2O3

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; sodium azide / dimethyl sulfoxide / 85 °C

2: hydrogen; palladium / methanol / 20 °C

With sodium azide; hydrogen; iodine; palladium; In methanol; dimethyl sulfoxide;

DOI:10.1039/d1sc03615g

upstream raw materials:

tert-butyl 4-(hydroxymethyl)-4-(prop-2-en-1-yl)piperidine-1-carboxylate

Refernces