4-Allyl-4-Hydroxymethyl-Piperidine-1-Carboxylic Acid Tert-Butyl Ester

Base Information

• Chemical Name: 4-Allyl-4-Hydroxymethyl-Piperidine-1-Carboxylic Acid Tert-Butyl Ester
• CAS No.: 236406-37-4
• Molecular Formula: C₁₄H₂₅NO₃
• Molecular Weight: 255.357
• Mol file: 236406-37-4.mol

Synonyms:4-allyl-N-t-butoxycarbonylpiperidine-4-methanol;4-Allyl-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 4-Allyl-4-Hydroxymethyl-Piperidine-1-Carboxylic Acid Tert-Butyl Ester

Chemical Property:

• PSA: 49.77000
• LogP: 2.51000

Purity/Quality:

97% ^*data from raw suppliers

4-Allyl-4-Hydroxymethyl-Piperidine-1-CarboxylicAcidTert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Allyl-4-Hydroxymethyl-Piperidine-1-Carboxylic Acid Tert-Butyl Ester

There total 4 articles about 4-Allyl-4-Hydroxymethyl-Piperidine-1-Carboxylic Acid Tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butyl) 4-methyl 4-allylpiperidine-1,4-dicarboxylate (441774-09-0) → tert-butyl 4-(hydroxymethyl)-4-(prop-2-en-1-yl)piperidine-1-carboxylate (236406-37-4)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

DOI:10.1016/j.bmcl.2004.06.049

Reference yield:

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate (146603-99-8) → tert-butyl 4-(hydroxymethyl)-4-(prop-2-en-1-yl)piperidine-1-carboxylate (236406-37-4)

Guidance literature:

Reference yield:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) → tert-butyl 4-(hydroxymethyl)-4-(prop-2-en-1-yl)piperidine-1-carboxylate (236406-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: DIBAL / CH₂Cl₂ / -78 °C

With diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2004.06.049

upstream raw materials:

1-(tert-butyl) 4-methyl 4-allylpiperidine-1,4-dicarboxylate

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate

Downstream raw materials:

tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate

4-(4-hydroxy-phenylsulfanylmethyl)-4-methoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

4-carboxymethyl-4-(4-hydroxy-phenylsulfanylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

4-methoxycarbonylmethyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1-carboxylic acid tert-butyl ester