Tert-butyl 4-[1-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-[1-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate
CAS No.:191034-03-4
Molecular Formula:C₁₇H₂₅FN₂O₃
Molecular Weight:324.396
Hs Code.:
DSSTox Substance ID:DTXSID50702264
Mol file:191034-03-4.mol

Synonyms:tert-butyl 4-[1-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate;191034-03-4;SCHEMBL8470525;DTXSID50702264;PEOAEYYVBAITME-UHFFFAOYSA-N;EN300-12461331

Suppliers and Price of Tert-butyl 4-[1-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-[1-(4-FLUORO-PHENYL)-2-HYDROXY-ETHYL]PIPERAZINE-1-CARBOXYLIC ACID-TERT-BUTYL ESTER 95.00%
5MG
$ 497.92

Total 0 raw suppliers

Chemical Property of Tert-butyl 4-[1-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate

Chemical Property:

PSA：53.01000
LogP:2.28760
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:324.18492083
Heavy Atom Count:23
Complexity:384

Purity/Quality:: 4-[1-(4-FLUORO-PHENYL)-2-HYDROXY-ETHYL]PIPERAZINE-1-CARBOXYLIC ACID-TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(CC1)C(CO)C2=CC=C(C=C2)F

Technology Process of Tert-butyl 4-[1-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate

There total 5 articles about Tert-butyl 4-[1-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 191034-03-4
2-[4-tert-Butyloxycarbonylpiperazin-1-yl]2-[4-fluorophenyl]ethan-1-ol

Guidance literature:

Reference yield:

: 191033-99-5
4-[(4-fluoro-phenyl)-methoxycarbonyl-methyl]-piperazine-1-carboxylic acid tert-butyl ester

: 191034-03-4
2-[4-tert-Butyloxycarbonylpiperazin-1-yl]2-[4-fluorophenyl]ethan-1-ol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; Heating;
DOI:10.1016/S0960-894X(02)00563-2

Reference yield:

: 71783-54-5
methyl 2-bromo-2-(4-fluorophenyl)acetate

: 191034-03-4
2-[4-tert-Butyloxycarbonylpiperazin-1-yl]2-[4-fluorophenyl]ethan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 20 °C

2: LiBH₄ / tetrahydrofuran / Heating

With lithium borohydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00563-2