(2-HYDROXYPHENYL)(O-TOLYL)METHANONE

Base Information

• Chemical Name: (2-HYDROXYPHENYL)(O-TOLYL)METHANONE
• CAS No.: 51974-19-7
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Mol file: 51974-19-7.mol

Synonyms:(2-HYDROXYPHENYL)(O-TOLYL)METHANONE

Chemical Property of (2-HYDROXYPHENYL)(O-TOLYL)METHANONE

Chemical Property:

• Melting Point: 65–67°C
• PSA: 37.30000
• LogP: 2.93160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-HYDROXYPHENYL)(O-TOLYL)METHANONE

There total 23 articles about (2-HYDROXYPHENYL)(O-TOLYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

5-chloro-2-hydroxy-2'-methylbenzophenone (52980-94-6) → (2-hydroxyphenyl)(o-tolyl)methanone (51974-19-7)

Guidance literature:

With hydrogen; potassium acetate; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;

DOI:10.1248/cpb.43.616

Reference yield: 89.0%

C15H12O2 → (2-hydroxyphenyl)(o-tolyl)methanone (51974-19-7)

Guidance literature:

With di-tert-butyl peroxide; sodium carbonate; nickel dichloride; In toluene; at 80 ℃; for 12h;

Reference yield: 88.0%

ortho-methylphenyl iodide (615-37-2) + salicylaldehyde (90-02-8) → (2-hydroxyphenyl)(o-tolyl)methanone (51974-19-7)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; palladium dichloride; In water; at 100 ℃; for 13h; Green chemistry;

DOI:10.1016/j.molcata.2014.10.013

upstream raw materials:

(2-aminophenyl)(2-methylphenyl)methanone

5-chloro-2-hydroxy-2'-methylbenzophenone

hydrogenchloride

2-methyl-benzoic acid-(4-chloro-phenyl ester)

Downstream raw materials:

2-Oxo-4-o-tolyl-2H-chromene-3-carboxylic acid ethyl ester

(4R)-4-(2-tolyl)-3,4-dihydro-1,2,3-benzoxathiazine-2,2-dioxide

2-Oxo-4-o-tolyl-2H-chromene-3-carboxylic acid

3-Isocyanato-4-o-tolyl-chromen-2-one

Refernces

• 1、 Hu, Le' an,Zhang, Yao,Zhang, Qing-Wen,Yin, Qin,Zhang, Xumu. "Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2". . p. 5321 - 5325. Retrieved 2020/02/28.
• 2、 -. "Efficient catalytic synthesis method of 2-hydroxybenzophenone compound". Paragraph 0021; 0022. . Retrieved 2019/04/11.