2-Chloro-3-methyl-4-pyridinemethanol

Base Information

• Chemical Name: 2-Chloro-3-methyl-4-pyridinemethanol
• CAS No.: 329794-45-8
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.6
• Mol file: 329794-45-8.mol

Synonyms:2-Chloro-3-methyl-4-pyridinemethanol;(2-Chloro-3-methylpyridin-4-yl)methanol

Chemical Property of 2-Chloro-3-methyl-4-pyridinemethanol

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 298.911°C at 760 mmHg
• Flash Point: 134.577°C
• PSA: 33.12000
• Density: 1.264g/cm³
• LogP: 1.53570

Purity/Quality:

98% ^*data from raw suppliers

(2-Chloro-3-methylpyridin-4-yl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-methyl-4-pyridinemethanol

There total 1 articles about 2-Chloro-3-methyl-4-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

3-Methyl-1-oxy-isonicotinic acid ethyl ester (301666-87-5) → (2-chloro-3-methylpyridin-4-yl)methanol (329794-45-8) + (2-chloro-5-methylpyridin-4-yl)methanol (479612-36-7)

Guidance literature:

3-Methyl-1-oxy-isonicotinic acid ethyl ester; With trichlorophosphate; for 3h; Heating;

With lithium borohydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm049697f

Reference yield:

(2-chloro-3-methylpyridin-4-yl)methanol (329794-45-8) → benzhydrylidene-[4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-pyridin-2-yl]-amine

Guidance literature:

Multi-step reaction with 2 steps

1: 8.89 g / imidazole / dimethylformamide

2: NaOtBu; BINAP racemic; Pd₂(dba)3 / toluene / 3 h / 80 °C

With 1H-imidazole; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm049697f

upstream raw materials:

3-Methyl-1-oxy-isonicotinic acid ethyl ester

Refernces