6-Chloro-3-methyl-4-pyridinemethanol

Base Information

Chemical Name:6-Chloro-3-methyl-4-pyridinemethanol
CAS No.:479612-36-7
Molecular Formula:C7H8ClNO
Molecular Weight:157.59752
Hs Code.:
Mol file:479612-36-7.mol

Synonyms:6-Chloro-3-methyl-4-pyridinemethanol

Suppliers and Price of 6-Chloro-3-methyl-4-pyridinemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of 6-Chloro-3-methyl-4-pyridinemethanol

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:301.702°C at 760 mmHg
Flash Point:136.265°C
PSA：33.12000
Density:1.264g/cm³
LogP:1.53570

Purity/Quality:: HPLC≥98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Chloro-3-methyl-4-pyridinemethanol

There total 7 articles about 6-Chloro-3-methyl-4-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 787596-43-4
methyl 2-chloro-5-methylisonicotinate

: 479612-36-7
(2-chloro-5-methylpyridin-4-yl)methanol

Guidance literature:: methyl 2-chloro-5-methylisonicotinate; With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; at 10 - 25 ℃; for 5h; Large scale;

With hydrogenchloride; In water; at 20 ℃; for 4h; Large scale;

Reference yield: 48.0%

: 301666-87-5
3-Methyl-1-oxy-isonicotinic acid ethyl ester

: 329794-45-8
(2-chloro-3-methylpyridin-4-yl)methanol

: 479612-36-7
(2-chloro-5-methylpyridin-4-yl)methanol

Guidance literature:: 3-Methyl-1-oxy-isonicotinic acid ethyl ester; With trichlorophosphate; for 3h; Heating;

With lithium borohydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jm049697f

Reference yield:

: 58997-11-8
3-methylisonicotinic acid ethyl ester

: 479612-36-7
(2-chloro-5-methylpyridin-4-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / methyl trioxorhenium; aq. H₂O₂ / CH₂Cl₂

2.1: POCl₃ / 3 h / Heating

2.2: 20 percent / LiBH₄ / tetrahydrofuran / 2 h / Heating

With dihydrogen peroxide; methyltrioxorhenium(VII); trichlorophosphate; In dichloromethane;
DOI:10.1021/jm049697f